[HTML][HTML] Mitochondrial dysfunction route as a possible biomarker and therapy target for human cancer

R Al-Faze, HA Ahmed, MA El-Atawy, H Zagloul… - Biomedical Journal, 2024 - Elsevier
Mitochondria are vital organelles found within living cells and have signalling, biosynthetic,
and bioenergetic functions. Mitochondria play a crucial role in metabolic reprogramming …

Synthesis, characterization, and anticancer activity of new N, N′-Diarylthiourea derivative against breast cancer cells

MA El-Atawy, MS Alsubaie, ML Alazmi, EA Hamed… - Molecules, 2023 - mdpi.com
The goal of the current study was to prepare two new homologous series of N, N′-
diarylurea and N, N′-diarylthiourea derivatives to investigate the therapeutic effects of …

The cross talk between type II diabetic microenvironment and the regenerative capacities of human adipose tissue-derived pericytes: a promising cell therapy

TA Ahmed, SM Ahmed, H Elkhenany… - Stem Cell Research & …, 2024 - Springer
Abstract Background Pericytes (PCs) are multipotent contractile cells that wrap around the
endothelial cells (ECs) to maintain the blood vessel's functionality and integrity. The …

Synthesis, Characterization, Antioxidant, and Anticancer Activity against Colon Cancer Cells of Some Cinnamaldehyde-Based Chalcone Derivatives

MA El-Atawy, DH Hanna, AH Bashal, HA Ahmed… - Biomolecules, 2024 - mdpi.com
The purpose of the current investigation was to produce cinammaldehyde-based chalcone
derivatives (3a–k) to evaluate their potential effectiveness as antioxidant and inhibitory …

The protective effect of aqueous extract of Stevia rebaudiana against tartrazine toxicity in male Wistar rat

DH Hanna, SN Beshay, E El. Shafee… - Cell Biochemistry …, 2023 - Wiley Online Library
Tartrazine is a yellow colouring agent that is commonly used in foods; however, high
dosages of Tartrazine affect fertility and create oxidative stress by generating free radicals. A …

Unlocking the Therapeutic Potential of Stevia rebaudiana Bertoni: A Natural Antiglycating Agent and Non-Toxic Support for HDF Cell Health

R Shahu, D Kumar, A Ali, K Tungare, KM Al-Anazi… - Molecules, 2023 - mdpi.com
Sugar carbonyl groups interact with protein amino groups, forming toxic components
referred to as advanced glycation end products (AGEs). The glycation system (BSA, a model …

Biological Applications of Thiourea Derivatives: Detailed Review

FA Agili - Chemistry, 2024 - mdpi.com
Thiourea and its derivatives have become a significant focal point within the organic
synthesis field, garnering attention for their diverse biological applications, including …

Shikimic Acid Nanoformulations: a Comprehensive Inquiry into Anticancer Potential and Apoptotic Induction on A2058 Skin Cancer Cells

P Meghdadi, FF Bamoharram, E Karimi, E Ghasemi - BioNanoScience, 2024 - Springer
Addressing the global challenge of cancer requires ongoing exploration of innovative
therapeutic approaches. Nanotechnology has emerged as a particularly promising avenue …

Stevia extract safeguards rats from diabetic renal injury by mitigating markers of inflammation, oxidative stress, and apoptosis

FM Othman, MR El-Sawi, SM Shabana - Toxicology and Environmental …, 2023 - Springer
Objective This study will figure out if stevia extract, a herb with anti-inflammatory and
antioxidant characteristics, is effective in treating diabetic nephropathy (DN) and protecting …