Eukaryotic cells are equipped with an intricate proteostasis network (PN), comprising nearly
3000 components dedicated to preserving proteome integrity and sustaining protein …

Recombinant proteins play pivotal roles in numerous applications including industrial
biocatalysts or therapeutics. Despite the recent progress in computational protein structure …

Insulin, an essential peptide hormone, conjointly regulates blood glucose levels by its
receptor and it is used as vital drug to treat diabetes. This therapeutic hormone may undergo …

Sensitive analytical techniques that are capable of detecting and quantifying disease-
associated biomolecules are indispensable in our efforts to understand disease …

The diffusion coefficients of globular and fully unfolded proteins can be predicted with high
accuracy solely from their mass or chain length. However, this approach fails for intrinsically …

Deposition of amyloid plaques in the brains of Alzheimer's disease (AD) patients is a
hallmark of the disease. AD plaques consist primarily of the beta-amyloid (Aβ) peptide but …

Motivation Proteins, the molecular workhorses of biological systems, execute a multitude of
critical functions dictated by their precise three-dimensional structures. In a complex and …

Both controllable regulation of the conformational structure of a polypeptide and specific
recognition of an amino acid are still arduous challenges. Here, a novel dual-mode …

More than 650 reversible and irreversible post-translational modifications (PTMs) of proteins
have been listed so far. Canonical PTMs of proteins consist of the covalent addition of …

Celiac disease (CeD) is an autoimmune disorder triggered by gluten proteins, affecting
approximately 1% of the global population. The 33‐mer deamidated gliadin peptide (DGP) …