Neutralizing antibodies for the prevention and treatment of COVID-19
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) initiates the infection
process by binding to the viral cellular receptor angiotensin-converting enzyme 2 through …
process by binding to the viral cellular receptor angiotensin-converting enzyme 2 through …
[HTML][HTML] Impact of COVID-19 in solid organ transplant recipients
L Danziger-Isakov, EA Blumberg, O Manuel… - American Journal of …, 2021 - Elsevier
The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) exploded onto the world stage in early …
respiratory syndrome coronavirus 2 (SARS-CoV-2) exploded onto the world stage in early …
Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants
Neutralizing antibodies (nAbs) elicited against the receptor binding site (RBS) of the spike
protein of wild-type severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are …
protein of wild-type severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are …
[HTML][HTML] Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection
SARS-CoV-2 has caused the global COVID-19 pandemic. Although passively delivered
neutralizing antibodies against SARS-CoV-2 show promise in clinical trials, their mechanism …
neutralizing antibodies against SARS-CoV-2 show promise in clinical trials, their mechanism …
[HTML][HTML] SARS-CoV-2 spike promotes inflammation and apoptosis through autophagy by ROS-suppressed PI3K/AKT/mTOR signaling
F Li, J Li, PH Wang, N Yang, J Huang, J Ou, T Xu… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Background Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection-
induced inflammatory responses are largely responsible for the death of novel coronavirus …
induced inflammatory responses are largely responsible for the death of novel coronavirus …
Human B cell clonal expansion and convergent antibody responses to SARS-CoV-2
B cells are critical for the production of antibodies and protective immunity to viruses. Here
we show that patients infected with severe acute respiratory syndrome coronavirus 2 (SARS …
we show that patients infected with severe acute respiratory syndrome coronavirus 2 (SARS …
Establishment of a well-characterized SARS-CoV-2 lentiviral pseudovirus neutralization assay using 293T cells with stable expression of ACE2 and TMPRSS2
SN Neerukonda, R Vassell, R Herrup, S Liu, T Wang… - PloS one, 2021 - journals.plos.org
Pseudoviruses are useful surrogates for highly pathogenic viruses because of their safety,
genetic stability, and scalability for screening assays. Many different pseudovirus platforms …
genetic stability, and scalability for screening assays. Many different pseudovirus platforms …
A single dose of recombinant VSV-∆ G-spike vaccine provides protection against SARS-CoV-2 challenge
Y Yahalom-Ronen, H Tamir, S Melamed, B Politi… - Nature …, 2020 - nature.com
The COVID-19 pandemic caused by SARS-CoV-2 imposes an urgent need for rapid
development of an efficient and cost-effective vaccine, suitable for mass immunization. Here …
development of an efficient and cost-effective vaccine, suitable for mass immunization. Here …
Deep geometric representations for modeling effects of mutations on protein-protein binding affinity
Modeling the impact of amino acid mutations on protein-protein interaction plays a crucial
role in protein engineering and drug design. In this study, we develop GeoPPI, a novel …
role in protein engineering and drug design. In this study, we develop GeoPPI, a novel …
Protective antibodies elicited by SARS-CoV-2 spike protein vaccination are boosted in the lung after challenge in nonhuman primates
JR Francica, BJ Flynn, KE Foulds, AT Noe… - Science translational …, 2021 - science.org
Adjuvanted soluble protein vaccines have been used extensively in humans for protection
against various viral infections based on their robust induction of antibody responses. Here …
against various viral infections based on their robust induction of antibody responses. Here …