[HTML][HTML] The robustness of cellular immunity determines the fate of SARS-CoV-2 infection

E Moga, E Lynton-Pons, P Domingo - Frontiers in immunology, 2022 - frontiersin.org
Two years after the appearance of the SARS-CoV-2 virus, the causal agent of the current
global pandemic, it is time to analyze the evolution of the immune protection that infection …

SARS-CoV-2 is restricted by zinc finger antiviral protein despite preadaptation to the low-CpG environment in humans

R Nchioua, D Kmiec, JA Müller, C Conzelmann, R Groß… - MBio, 2020 - Am Soc Microbiol
Recent evidence shows that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) is sensitive to interferons (IFNs). However, the most effective types of IFNs and the …

Immunogenicity of the BNT162b2 vaccine in frail or disabled nursing home residents: COVID‐A study

S Salmerón Ríos, M Mas Romero… - Journal of the …, 2021 - Wiley Online Library
Abstract Background/Objectives The safety and immunogenicity of the BNT162b2
coronavirus disease 2019 (COVID‐19) vaccine in older adults with different frailty and …

Pharmaceutical aspects and clinical evaluation of COVID-19 vaccines

K Hofman, GN Shenoy, V Chak… - Immunological …, 2021 - Taylor & Francis
ABSTRACT COVID-19, the disease caused by the novel severe acute respiratory syndrome-
associated coronavirus 2 (SARS-CoV-2), was first detected in December 2019 and has …

[HTML][HTML] Changes in the immune response against SARS-CoV-2 in individuals with severe COVID-19 treated with high dose of vitamin D

M Torres, G Casado, L Vigón, S Rodríguez-Mora… - Biomedicine & …, 2022 - Elsevier
Main cause of severe illness and death in COVID-19 patients appears to be an excessive
but ineffectual inflammatory immune response that may cause severe acute respiratory …

Nucleocapsid and Spike Proteins of the Coronavirus SARS-CoV-2 Induce IL6 in Monocytes and Macrophages—Potential Implications for Cytokine Storm Syndrome

I Karwaciak, A Sałkowska, K Karaś, J Dastych… - Vaccines, 2021 - mdpi.com
The pandemic of the new coronavirus SARS-CoV-2 (severe acute respiratory syndrome
coronavirus 2) has led to the deaths of more than 1.5 million people worldwide. SARS-CoV …

Epigenetic landscapes of single-cell chromatin accessibility and transcriptomic immune profiles of T cells in COVID-19 patients

S Li, B Wu, Y Ling, M Guo, B Qin, X Ren… - Frontiers in …, 2021 - frontiersin.org
T cells play a critical role in coronavirus diseases. How they do so in COVID-19 may be
revealed by analyzing the epigenetic chromatin accessibility of cis-and trans-regulatory …

Innate immune response in SARS-CoV-2 infection

G Schiuma, S Beltrami, D Bortolotti, S Rizzo, R Rizzo - Microorganisms, 2022 - mdpi.com
An efficient host immune response is crucial in controlling viral infections. Despite most
studies focused on the implication of T and B cell response in COVID-19 (Corona Virus …

Spatially distributed infection increases viral load in a computational model of SARS-CoV-2 lung infection

ME Moses, S Hofmeyr, JL Cannon… - PLoS computational …, 2021 - journals.plos.org
A key question in SARS-CoV-2 infection is why viral loads and patient outcomes vary
dramatically across individuals. Because spatial-temporal dynamics of viral spread and …

Differential abundance of IgG antibodies against the spike protein of SARS-CoV-2 and seasonal coronaviruses in patients with fatal COVID-19

WL Smit, S van Tol, LEM Haas, GJM Limonard… - Virology Journal, 2023 - Springer
Infection with the novel pandemic SARS-CoV-2 virus has been shown to elicit a cross-
reactive immune response that could lead to a back-boost of memory recall to previously …