Klotho protein inhibits H2O2-induced oxidative injury in endothelial cells via regulation of PI3K/AKT/Nrf2/HO-1 pathways

W Cui, B Leng, GP Wang - Canadian Journal of Physiology and …, 2019 - cdnsciencepub.com
Klotho protein secreted in the blood could act as a hormone to regulate various target
organs and have a protective effect on the cardiovascular system. Numerous studies had …

Prevalence of atherosclerotic cardiovascular disease and subsequent major adverse cardiovascular events in Alberta, Canada: A real‐world evidence study

G Chen, MS Farris, T Cowling, L Pinto… - Clinical …, 2021 - Wiley Online Library
Background Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of morbidity
and mortality worldwide. Data from Canadian populations regarding the burden of ASCVD …

The Association between Serum Vitamin D concentration and new inflammatory biomarkers—systemic inflammatory index (SII) and systemic inflammatory response …

EA Dziedzic, JS Gąsior, A Tuzimek, M Dąbrowski… - Nutrients, 2022 - mdpi.com
The incidence of ischemic heart disease (IHD) increases every year. This cardiovascular
disease has an inflammatory factor in its etiology due to different immune cells that influence …

Cardiovascular effects of flavonoids

M Sánchez, M Romero… - Current medicinal …, 2019 - ingentaconnect.com
Cardiovascular Disease (CVD) is the major cause of death worldwide, especially in Western
society. Flavonoids are a large group of polyphenolic compounds widely distributed in …

Cardiovascular disease, diabetes and early exit from paid employment in Europe; the impact of work-related factors

TA Kouwenhoven-Pasmooij, A Burdorf… - International journal of …, 2016 - Elsevier
Background/objectives: The aims of the study were to examine (i) the association between
cardiovascular disease (CVD) or diabetes and exit from paid employment via disability …

Nrf2 signaling and redox homeostasis in the aging heart: A potential target to prevent cardiovascular diseases?

A Silva-Palacios, M Koenigsberg, C Zazueta - Ageing research reviews, 2016 - Elsevier
Aging process is often accompanied with a high incidence of cardiovascular diseases (CVD)
due to the synergistic effects of age-related changes in heart morphology/function and …

Role of chemerin in cardiovascular diseases

MT Macvanin, M Rizzo, J Radovanovic, A Sonmez… - Biomedicines, 2022 - mdpi.com
(1) Background: Obesity is closely connected to the pathophysiology of cardiovascular
diseases (CVDs). Excess fat accumulation is associated with metabolic malfunctions that …

Dietary polyphenols for atherosclerosis: A comprehensive review and future perspectives

R Bahramsoltani, F Ebrahimi, MH Farzaei… - Critical reviews in …, 2019 - Taylor & Francis
Atherosclerosis is one of the most prevalent reasons for premature death in adults. Despite
the several conventional drugs in the market; many patients are not completely treated. Here …

[HTML][HTML] Induced pluripotent stem cell–derived endothelial cells: overview, current advances, applications, and future directions

S Jang, AC de l'Hortet, A Soto-Gutierrez - The American Journal of …, 2019 - Elsevier
Endothelial cells are prevalent in our bodies and serve multiple functions. By lining the
vasculature, they provide a barrier to tissues and facilitate the transport of molecules and …

Rise and fall of elastic fibers from development to aging. Consequences on arterial structure-function and therapeutical perspectives

W Fhayli, Q Boëté, O Harki, A Briançon-Marjollet… - Matrix Biology, 2019 - Elsevier
In the arteries of vertebrates, evolution has given rise to resilient macromolecular structures,
elastin and elastic fibers, capable of sustaining an elevated blood pressure and …