Eukaryotes are divided into two major compartments: the nucleus where RNA is synthesized
and processed, and the cytoplasm, where mRNA is translated into proteins. Although many …

Long noncoding RNAs (lncRNAs) have emerged as regulators of diverse cellular processes.
Although the vast majority of lncRNAs are expressed at lower levels compared to …

Main conclusion Long non-coding RNAs modulate gene activity in plant development and
stress responses by various molecular mechanisms. Abstract Long non-coding RNAs …

The chromatin regulator FACT (facilitates chromatin transcription) is essential for ensuring
stable gene expression by promoting transcription. In a genetic screen using Caenorhabditis …

It is now evident that noncoding RNAs play key roles in regulatory networks determining cell
fate and behavior, in a myriad of different conditions, and across all species. Among these …

The past decade has seen an explosion of interest in long noncoding RNAs (lncRNAs).
However, despite the massive volume of scientific data implicating these transcripts in a …

Activity-dependent structural plasticity at the synapse requires specific changes in the
neuronal transcriptome. While much is known about the role of coding elements in this …

The human transcriptome contains thousands of long non-coding RNAs (lncRNAs).
Characterizing their function is a current challenge. An emerging concept is that lncRNAs …

The division of the cellular space into nucleoplasm and cytoplasm promotes quality control
mechanisms that prevent misprocessed mRNAs and junk RNAs from gaining access to the …

Transcription termination pathways mitigate the detrimental consequences of unscheduled
promiscuous initiation occurring at hundreds of thousands of genomic cis-regulatory …