The sequence domains underlying long noncoding RNA (lncRNA) activities, including their
characteristic nuclear enrichment, remain largely unknown. It has been proposed that these …

Despite the growing evidence suggesting that long noncoding RNAs (lncRNAs) are critical
regulators of several biological processes, their functions in the nervous system remain …

Nuclear retention of incompletely spliced or mature mRNAs emerges as a novel, previously
underappreciated layer of gene regulation, which enables the cell to rapidly respond to …

Eukaryotic cells synthesize enormous quantities of RNA from diverse classes, most of which
are subject to extensive processing. These processes are inherently error-prone, and cells …

Breast cancer is a common cancer in women and a leading cause of mortality. With the early
diagnosis and development of therapeutic drugs, the prognosis of breast cancer has …

RNA-binding proteins (RBPs) control and coordinate each stage in the life cycle of RNAs.
Although in vivo binding sites of RBPs can now be determined genome-wide, most studies …

Fragile X syndrome (FXS) is caused by inactivation of the FMR1 gene and loss of encoded
FMRP, an RNA binding protein that represses translation of some of its target transcripts …

Despite gene expression programs being notoriously complex, RNA abundance is usually
assumed as a proxy for transcriptional activity. Recently developed approaches, able to …

Long noncoding RNAs (lncRNAs), which are longer than 200 nucleotides but often unstable,
contribute a substantial and diverse portion to pervasive noncoding transcriptomes. Most …

Long non-coding RNAs (lncRNAs) have gained increasing attention as they exhibit highly
tissue-and cell-type specific expression patterns. LncRNAs are highly expressed in the …