Machine learning approaches on high throughput NGS data to unveil mechanisms of function in biology and disease

VC Pezoulas, O Hazapis, N Lagopati… - Cancer genomics & …, 2021 - cgp.iiarjournals.org
In this review, the fundamental basis of machine learning (ML) and data mining (DM) are
summarized together with the techniques for distilling knowledge from state-of-the-art omics …

Genome-wide dynamics of RNA synthesis, processing, and degradation without RNA metabolic labeling

M Furlan, E Galeota, N Del Gaudio, E Dassi… - Genome …, 2020 - genome.cshlp.org
The quantification of the kinetic rates of RNA synthesis, processing, and degradation are
largely based on the integrative analysis of total and nascent transcription, the latter being …

SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells

EAA Obara, D Aguilar-Morante, RD Rasmussen… - Nature …, 2020 - nature.com
Glioblastoma cancer-stem like cells (GSCs) display marked resistance to ionizing radiation
(IR), a standard of care for glioblastoma patients. Mechanisms underpinning radio …

Comparative genomics in the search for conserved long noncoding RNAs

MW Szcześniak, MR Kubiak, E Wanowska… - Essays in …, 2021 - portlandpress.com
Long noncoding RNAs (lncRNAs) have emerged as prominent regulators of gene
expression in eukaryotes. The identification of lncRNA orthologs is essential in efforts to …

Timing is everything: advances in quantifying splicing kinetics

HE Merens, K Choquet, AR Baxter-Koenigs… - Trends in Cell …, 2024 - cell.com
Splicing is a highly regulated process critical for proper pre-mRNA maturation and the
maintenance of a healthy cellular environment. Splicing events are impacted by ongoing …

LncRNA12097. 1 contributes to endometrial cell growth by enhancing YES1 activating β-catenin via sponging miR-145-5p

X Li, K Li, K Deng, Z Liu, X Huang, J Guo… - International Journal of …, 2024 - Elsevier
Despite previous investigations elucidating the regulatory mechanisms of long non-coding
RNAs (lncRNAs) in endometrial function and reproductive disorders, the precise pathways …

Long non-coding RNAs in osteoporosis: from mechanisms of action to therapeutic potential

J Hou, D Liu, J Zhao, S Qin, S Chen, Z Zhou - Human Cell, 2023 - Springer
Osteoporosis is a clinical disease characterized by decreased bone density due to a
disrupted balance between bone formation and resorption, which increases fracture risk and …

[HTML][HTML] Long non-coding RNAs in cutaneous melanoma: clinical perspectives

E Hulstaert, L Brochez, PJ Volders, J Vandesompele… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Metastatic melanoma of the skin has a high mortality despite the recent introduction of
targeted therapy and immunotherapy. Long non-coding RNAs (lncRNAs) are defined as …

Identification of long non-coding RNA in formaldehyde-induced cardiac dysplasia in rats

L Zhang, Y Yang, L Zhang, J Ma, R Sun, Y Tian… - Food and Chemical …, 2023 - Elsevier
Formaldehyde exposure during pregnancy can cause fetal congenital heart disease (CHD).
However, the regulatory mechanism remains unclear. Studies on the biology of long non …

Landscape of the noncoding transcriptome response of two Arabidopsis ecotypes to phosphate starvation

T Blein, C Balzergue, T Roulé, M Gabriel… - Plant …, 2020 - academic.oup.com
Root architecture varies widely between species; it even varies between ecotypes of the
same species, despite strong conservation of the coding portion of their genomes. By …