Extracellular vesicles and their cells of origin: Open issues in autoimmune diseases

A Haghighitalab, M Dominici, MM Matin… - Frontiers in …, 2023 - frontiersin.org
The conventional therapeutic approaches to treat autoimmune diseases through
suppressing the immune system, such as steroidal and non-steroidal anti-inflammatory …

[HTML][HTML] Factors affecting osteogenesis and chondrogenic differentiation of mesenchymal stem cells in osteoarthritis

Y Peng, H Jiang, HD Zuo - World Journal of Stem Cells, 2023 - ncbi.nlm.nih.gov
Osteoarthritis (OA) is a common degenerative joint disease that often involves progressive
cartilage degeneration and bone destruction of subchondral bone. At present, clinical …

Role of mesenchymal stem cells and their paracrine mediators in macrophage polarization: an approach to reduce inflammation in osteoarthritis

SS Kuppa, HK Kim, JY Kang, SC Lee… - International Journal of …, 2022 - mdpi.com
Osteoarthritis (OA) is a low-grade inflammatory disorder of the joints that causes
deterioration of the cartilage, bone remodeling, formation of osteophytes, meniscal damage …

Application of mesenchymal stem cells (MSCs) in neurodegenerative disorders: history, findings, and prospective challenges

N Biglari, A Mehdizadeh, MV Mastanabad… - … -Research and Practice, 2023 - Elsevier
Over the past few decades, the application of mesenchymal stem cells has captured the
attention of researchers and practitioners worldwide. These cells can be obtained from …

Adipose-derived stem cells ameliorate atopic dermatitis by suppressing the IL-17 expression of Th17 cells in an ovalbumin-induced mouse model

J Guan, Y Li, F Lu, J Feng - Stem Cell Research & Therapy, 2022 - Springer
Abstract Background Mesenchymal stem cells (MSCs) have therapeutic potential for atopic
dermatitis (AD) owing to their immunoregulatory effects. However, the underlying …

Current treatments after spinal cord injury: Cell engineering, tissue engineering, and combined therapies

Y Shen, X Cao, M Lu, H Gu, M Li, DA Posner - Smart Medicine, 2022 - Wiley Online Library
Both traumatic and non‐traumatic spinal cord injuries (SCIs) can be categorized as
damages done to our central nervous system (CNS). The patients' physical and mental …

Practical considerations for translating mesenchymal stromal cell-derived extracellular vesicles from bench to bed

PPY Lui, YT Leung - Pharmaceutics, 2022 - mdpi.com
Extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) have shown
potential for the treatment of tendon and ligament injuries. This approach can eliminate the …

[HTML][HTML] The NLRP3 molecule influences the therapeutic effects of mesenchymal stem cells through Glut1-mediated energy metabolic reprogramming

J Chen, S Xie, D Qiu, M Xie, M Wu, X Li, X Zhang… - Journal of Advanced …, 2023 - Elsevier
Introduction Numerous studies demonstrated that NLRP3 has been implicated in the
pathogenesis of inflammatory bowel disease (IBD). Mesenchymal stem cells (MSCs) …

Novel vascular roles of human endoglin in pathophysiology

E Rossi, C Bernabeu - Journal of Thrombosis and Haemostasis, 2023 - Elsevier
Endoglin, alias CD105, is a human membrane glycoprotein highly expressed in vascular
endothelial cells. It is involved in angiogenesis and in angiogenesis-related diseases …

Hepatic stellate cells: current state and open questions

C Kordes, HH Bock, D Reichert, P May… - Biological …, 2021 - degruyter.com
This review article summarizes 20 years of our research on hepatic stellate cells within the
framework of two collaborative research centers CRC575 and CRC974 at the Heinrich …