Post‐translational modifications of histones: Mechanisms, biological functions, and therapeutic targets
R Liu, J Wu, H Guo, W Yao, S Li, Y Lu, Y Jia… - MedComm, 2023 - Wiley Online Library
Histones are DNA‐binding basic proteins found in chromosomes. After the histone
translation, its amino tail undergoes various modifications, such as methylation, acetylation …
translation, its amino tail undergoes various modifications, such as methylation, acetylation …
Glioblastoma: current status, emerging targets, and recent advances
Glioblastoma (GBM) is a highly malignant brain tumor characterized by a heterogeneous
population of genetically unstable and highly infiltrative cells that are resistant to …
population of genetically unstable and highly infiltrative cells that are resistant to …
Histone lysine demethylases as targets for anticancer therapy
It has recently been demonstrated that the genes controlling the epigenetic programmes that
are required for maintaining chromatin structure and cell identity include genes that drive …
are required for maintaining chromatin structure and cell identity include genes that drive …
The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells
Using a mouse model of human MLL-AF9 leukemia, we identified the lysine-specific
demethylase KDM1A (LSD1 or AOF2) as an essential regulator of leukemia stem cell (LSC) …
demethylase KDM1A (LSD1 or AOF2) as an essential regulator of leukemia stem cell (LSC) …
Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells
The histone demethylase LSD1 (KDM1A) demethylates mono-and di-methylated (Me2)
lysine (K) 4 on histone H3. High LSD1 expression blocks differentiation and confers a poor …
lysine (K) 4 on histone H3. High LSD1 expression blocks differentiation and confers a poor …
[HTML][HTML] Long non-coding RNA HOTAIR promotes glioblastoma cell cycle progression in an EZH2 dependent manner
The long non-coding RNA Hox transcript antisense intergenic RNA (HOTAIR) was recently
implicated in breast cancer metastasis and is predictive of poor prognosis in colorectal and …
implicated in breast cancer metastasis and is predictive of poor prognosis in colorectal and …
Re-programing chromatin with a bifunctional LSD1/HDAC inhibitor induces therapeutic differentiation in DIPG
JN Anastas, BM Zee, JH Kalin, M Kim, R Guo… - Cancer cell, 2019 - cell.com
Summary H3K27M mutations resulting in epigenetic dysfunction are frequently observed in
diffuse intrinsic pontine glioma (DIPGs), an incurable pediatric cancer. We conduct a …
diffuse intrinsic pontine glioma (DIPGs), an incurable pediatric cancer. We conduct a …
Comprehensive review for anticancer hybridized multitargeting HDAC inhibitors
AKA Bass, MS El-Zoghbi, ESM Nageeb… - European journal of …, 2021 - Elsevier
Despite the encouraging clinical progress of chemotherapeutic agents in cancer treatment,
innovation and development of new effective anticancer candidates still represents a …
innovation and development of new effective anticancer candidates still represents a …
Epidrug repurposing: discovering new faces of old acquaintances in cancer therapy
M Montalvo-Casimiro, R González-Barrios… - Frontiers in …, 2020 - frontiersin.org
Gene mutations are strongly associated with tumor progression and are well known in
cancer development. However, recently discovered epigenetic alterations have shown the …
cancer development. However, recently discovered epigenetic alterations have shown the …
LSD1-directed therapy affects glioblastoma tumorigenicity by deregulating the protective ATF4-dependent integrated stress response
S Faletti, D Osti, E Ceccacci, C Richichi… - Science Translational …, 2021 - science.org
Glioblastoma (GBM) is a fatal tumor whose aggressiveness, heterogeneity, poor blood-brain
barrier penetration, and resistance to therapy highlight the need for new targets and clinical …
barrier penetration, and resistance to therapy highlight the need for new targets and clinical …