Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer
To identify new susceptibility loci to lung cancer among diverse populations, we performed
cross-ancestry genome-wide association studies in European, East Asian and African …
cross-ancestry genome-wide association studies in European, East Asian and African …
Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts
Deciphering the shared genetic basis of distinct cancers has the potential to elucidate
carcinogenic mechanisms and inform broadly applicable risk assessment efforts. Here, we …
carcinogenic mechanisms and inform broadly applicable risk assessment efforts. Here, we …
Functional studies of lung cancer GWAS beyond association
Fourteen years after the first genome-wide association study (GWAS) of lung cancer was
published, approximately 45 genomic loci have now been significantly associated with lung …
published, approximately 45 genomic loci have now been significantly associated with lung …
Genetic epidemiology of breast cancer in Latin America
The last 10 years witnessed an acceleration of our understanding of what genetic factors
underpin the risk of breast cancer. Rare high-and moderate-penetrance variants such as …
underpin the risk of breast cancer. Rare high-and moderate-penetrance variants such as …
Allelic imbalance of chromatin accessibility in cancer identifies candidate causal risk variants and their mechanisms
While many germline cancer risk variants have been identified through genome-wide
association studies (GWAS), the mechanisms by which these variants operate remain …
association studies (GWAS), the mechanisms by which these variants operate remain …
The relationship between circulating lipids and breast cancer risk: A Mendelian randomization study
Background A number of epidemiological and genetic studies have attempted to determine
whether levels of circulating lipids are associated with risks of various cancers, including …
whether levels of circulating lipids are associated with risks of various cancers, including …
Genome-wide association analyses of breast cancer in women of African ancestry identify new susceptibility loci and improve risk prediction
We performed genome-wide association studies of breast cancer including 18,034 cases
and 22,104 controls of African ancestry. Genetic variants at 12 loci were associated with …
and 22,104 controls of African ancestry. Genetic variants at 12 loci were associated with …
Pan-cancer and cross-population genome-wide association studies dissect shared genetic backgrounds underlying carcinogenesis
G Sato, Y Shirai, S Namba, R Edahiro… - Nature …, 2023 - nature.com
Integrating genomic data of multiple cancers allows de novo cancer grouping and
elucidating the shared genetic basis across cancers. Here, we conduct the pan-cancer and …
elucidating the shared genetic basis across cancers. Here, we conduct the pan-cancer and …
A shared genetic contribution to breast cancer and schizophrenia
An association between schizophrenia and subsequent breast cancer has been suggested;
however the risk of schizophrenia following a breast cancer is unknown. Moreover, the …
however the risk of schizophrenia following a breast cancer is unknown. Moreover, the …
Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts
Even distinct cancer types share biological hallmarks. Here, we investigate polygenic risk
score (PRS)-specific pleiotropy across 16 cancers in European ancestry individuals from the …
score (PRS)-specific pleiotropy across 16 cancers in European ancestry individuals from the …