MicroRNAs and viral infection

CS Sullivan, D Ganem - Molecular cell, 2005 - cell.com
MicroRNAs (miRNAs) play a pivotal role in the regulation of genes involved in diverse
processes such as development, differentiation, and cellular growth control. Recently, many …

Systematic analysis of viral and cellular microRNA targets in cells latently infected with human γ-herpesviruses by RISC immunoprecipitation assay

L Dölken, G Malterer, F Erhard, S Kothe, CC Friedel… - Cell host & …, 2010 - cell.com
The mRNA targets of microRNAs (miRNAs) can be identified by immunoprecipitation of
Argonaute (Ago) protein-containing RNA-induced silencing complexes (RISCs) followed by …

KSHV: pathways to tumorigenesis and persistent infection

L Giffin, B Damania - Advances in virus research, 2014 - Elsevier
Kaposi's sarcoma-associated herpesvirus (KSHV; also known as human herpesvirus 8) is
the etiologic agent of Kaposi's sarcoma, primary effusion lymphoma, and multicentric …

Viruses and microRNAs: RISCy interactions with serious consequences

BR Cullen - Genes & development, 2011 - genesdev.cshlp.org
Analyses of small RNA expression profiles have revealed that several DNA viruses—
including particularly, herpesviruses—express high levels of multiple viral microRNAs …

Prediction and identification of herpes simplex virus 1-encoded microRNAs

C Cui, A Griffiths, G Li, LM Silva, MF Kramer… - Journal of …, 2006 - Am Soc Microbiol
MicroRNAs (miRNAs) are key regulators of gene expression in higher eukaryotes. Recently,
miRNAs have been identified from viruses with double-stranded DNA genomes. To attempt …

Gammaherpesvirus and lymphoproliferative disorders in immunocompromised patients

E Cesarman - Cancer letters, 2011 - Elsevier
Two lymphotropic human gamma herpesviruses can cause lymphoproliferative disorders:
Epstein Barr virus (EBV, formally designated as human herpesvirus 4) and Kaposi sarcoma …

Therapeutic potential for microRNAs

CC Esau, BP Monia - Advanced drug delivery reviews, 2007 - Elsevier
MiRNAs are a conserved class of non-coding RNAs that negatively regulate gene
expression post-transcriptionally. Although their biological roles are largely unknown …

Ago HITS-CLIP expands understanding of Kaposi's sarcoma-associated herpesvirus miRNA function in primary effusion lymphomas

I Haecker, LA Gay, Y Yang, J Hu, AM Morse… - 2012 - journals.plos.org
KSHV is the etiological agent of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL),
and a subset of multicentricCastleman's disease (MCD). The fact that KSHV-encoded …

Marek's Disease Virus Encodes MicroRNAs That Map to meq and the Latency-Associated Transcript

J Burnside, E Bernberg, A Anderson, C Lu… - Journal of …, 2006 - Am Soc Microbiol
MicroRNAs (miRNAs) are a class of small (∼ 22-nucleotide) regulatory molecules that block
translation or induce degradation of target mRNAs. These have been identified in a wide …

Epigenetic regulation of Kaposi's sarcoma-associated herpesvirus latency by virus-encoded microRNAs that target Rta and the cellular Rbl2-DNMT pathway

F Lu, W Stedman, M Yousef, R Renne… - Journal of …, 2010 - Am Soc Microbiol
Kaposi's sarcoma-associated herpesvirus (KSHV) encodes a cluster of 12 microRNAs
(miRNAs) that are processed from a transcript that is embedded within the major latency …