Molecular biology of KSHV in relation to AIDS-associated oncogenesis

W Greene, K Kuhne, F Ye, J Chen, F Zhou… - Aids-Associated Viral …, 2007 - Springer
In 1872, the famed Hungarian dermatologist Moritz Kaposi characterized an “idiopathic
multiple pigmented sarcoma” which is now known as Kaposi's sarcoma (KS). 424 For most …

Kaposi's sarcoma-associated herpesvirus latent gene vFLIP inhibits viral lytic replication through NF-κB-mediated suppression of the AP-1 pathway: a novel …

FC Ye, FC Zhou, JP Xie, T Kang, W Greene… - Journal of …, 2008 - Am Soc Microbiol
Kaposi's sarcoma-associated herpesvirus (KSHV) latency is central to the evasion of host
immune surveillances and induction of KSHV-related malignancies. The mechanism of …

The Latency-Associated Nuclear Antigen, a Multifunctional Protein Central to Kaposi's Sarcoma-Associated Herpesvirus Latency

ME Ballestas, KM Kaye - Future microbiology, 2011 - Taylor & Francis
Latency-associated nuclear antigen (LANA) is encoded by the Kaposi's sarcoma (KS)-
associated herpesvirus (KSHV) open reading frame 73. LANA is expressed during latent …

Integrated systems biology analysis of KSHV latent infection reveals viral induction and reliance on peroxisome mediated lipid metabolism

ZE Sychev, A Hu, TA DiMaio, A Gitter, ND Camp… - PLoS …, 2017 - journals.plos.org
Kaposi's Sarcoma associated Herpesvirus (KSHV), an oncogenic, human gamma-
herpesvirus, is the etiological agent of Kaposi's Sarcoma the most common tumor of AIDS …

MicroRNA regulation of human herpesvirus latency

S Chen, Y Deng, D Pan - Viruses, 2022 - mdpi.com
Herpesviruses are ubiquitous human pathogens. After productive (lytic) infection, all human
herpesviruses are able to establish life-long latent infection and reactivate from it. Latent …

Transcripts encoding K12, v-FLIP, v-cyclin, and the microRNA cluster of Kaposi's sarcoma-associated herpesvirus originate from a common promoter

M Pearce, S Matsumura, AC Wilson - Journal of virology, 2005 - Am Soc Microbiol
Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of three
malignancies associated with AIDS and immunosuppression. Tumor cells harbor latent virus …

Characterization of hypovirus-derived small RNAs generated in the chestnut blight fungus by an inducible DCL-2-dependent pathway

X Zhang, GC Segers, Q Sun, F Deng… - Journal of virology, 2008 - Am Soc Microbiol
The disruption of one of two dicer genes, dcl-2, of the chestnut blight fungus Cryphonectria
parasitica was recently shown to increase susceptibility to mycovirus infection (GC Segers …

MicroRNAs and their emerging roles in immunology

KM Pauley, EKL Chan - Annals of the New York Academy of …, 2008 - Wiley Online Library
MicroRNAs (miRNAs) are evolutionarily conserved small noncoding RNAs that post‐
transcriptionally regulate gene expression by targeting specific messenger RNAs (mRNAs) …

Influenza A virus expresses high levels of an unusual class of small viral leader RNAs in infected cells

JL Umbach, HL Yen, LLM Poon, BR Cullen - MBio, 2010 - Am Soc Microbiol
Evidence has recently accumulated suggesting that small noncoding RNAs, and particularly
microRNAs, have the potential to strongly affect the replication and pathogenic potential of a …

Kaposi's sarcoma-associated herpesvirus-encoded microRNA miR-K12-11 attenuates transforming growth factor beta signaling through suppression of SMAD5

Y Liu, R Sun, X Lin, D Liang, Q Deng, K Lan - Journal of virology, 2012 - Am Soc Microbiol
Kaposi's sarcoma-associated herpesvirus (KSHV) encodes 12 pre-microRNAs (pre-
miRNAs). Current studies have shown that these miRNAs are involved in regulation of viral …