The genetically informed neurobiology of addiction (GINA) model
Addictions are heritable and unfold dynamically across the lifespan. One prominent
neurobiological theory proposes that substance-induced changes in neural circuitry promote …
neurobiological theory proposes that substance-induced changes in neural circuitry promote …
The collaborative study on the genetics of alcoholism: Sample and clinical data
The collaborative study on the genetics of alcoholism (COGA) is a multi‐site,
multidisciplinary project with the goal of identifying how genes are involved in alcohol use …
multidisciplinary project with the goal of identifying how genes are involved in alcohol use …
[HTML][HTML] Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals
Problematic alcohol use (PAU), a trait that combines alcohol use disorder and alcohol-
related problems assessed with a questionnaire, is a leading cause of death and morbidity …
related problems assessed with a questionnaire, is a leading cause of death and morbidity …
[HTML][HTML] Profiling neuronal methylome and hydroxymethylome of opioid use disorder in the human orbitofrontal cortex
G Rompala, ST Nagamatsu… - Nature …, 2023 - nature.com
Opioid use disorder (OUD) is influenced by genetic and environmental factors. While recent
research suggests epigenetic disturbances in OUD, this is mostly limited to DNA methylation …
research suggests epigenetic disturbances in OUD, this is mostly limited to DNA methylation …
[HTML][HTML] CpH methylome analysis in human cortical neurons identifies novel gene pathways and drug targets for opioid use disorder
ST Nagamatsu, G Rompala, YL Hurd… - Frontiers in …, 2023 - frontiersin.org
Introduction DNA methylation (DNAm), an epigenetic mechanism, has been associated with
opioid use disorder (OUD) in preclinical and human studies. However, most of the studies …
opioid use disorder (OUD) in preclinical and human studies. However, most of the studies …
Specificity in genetic and environmental risk for prescription opioid misuse and heroin use
BackgroundMany studies aggregate prescription opioid misuse (POM) and heroin use into a
single phenotype, but emerging evidence suggests that their genetic and environmental …
single phenotype, but emerging evidence suggests that their genetic and environmental …
Identifying genetic loci and phenomic associations of substance use traits: A multi‐trait analysis of GWAS (MTAG) study
Abstract Background and Aims Genome‐wide association studies (GWAS) of opioid use
disorder (OUD) and cannabis use disorder (CUD) have lagged behind those of alcohol use …
disorder (OUD) and cannabis use disorder (CUD) have lagged behind those of alcohol use …
Genetic variants associated with opioid use disorder
Genetics are presumed to contribute 30–40% to opioid use disorder (OUD), allowing for the
possibility that genetic markers could be used to identify personal risk for developing OUD …
possibility that genetic markers could be used to identify personal risk for developing OUD …
[HTML][HTML] Single nuclei transcriptomics in human and non-human primate striatum in opioid use disorder
In brain, the striatum is a heterogenous region involved in reward and goal-directed
behaviors. Striatal dysfunction is linked to psychiatric disorders, including opioid use …
behaviors. Striatal dysfunction is linked to psychiatric disorders, including opioid use …
Cross-phenotype relationship between opioid use disorder and suicide attempts: new evidence from polygenic association and Mendelian randomization analyses
Y Huang, D Chen, AM Levin, BK Ahmedani… - Molecular …, 2023 - nature.com
Clinical epidemiological studies have found high co-occurrence between suicide attempts
(SA) and opioid use disorder (OUD). However, the patterns of correlation and causation …
(SA) and opioid use disorder (OUD). However, the patterns of correlation and causation …