The blood-brain barrier (BBB) functions as a highly selective border of endothelial cells,
protecting the central nervous system from potentially harmful substances by selectively …

The purinergic 2Y type 12 receptor (P2Y 12 R) is a well-known biological target for anti-
thrombotic drugs due to its role in platelet aggregation and blood clotting. While the …

The aim of this research is to examine possible neurological activity of methanol, ethyl
acetate, and aqueous extracts of Hygrophila spinosa and identify possible lead compounds …

Extensive phase II metabolic reactions (ie, glucuronidation and sulfation) have resulted in
low bioavailability and decreased biological effects of curcumin and quercetin. Compared to …

As a bioactive saponin derived from the seeds of Ziziphus jujuba Mill. var. spinosa (Bunge)
Hu ex HF Chow, jujuboside B (JuB) shows great potential in anti-anxiety, anti-depression …

This study presents the flow of Hibiscus Sabdariffa Roselle (Sobo), Soymilk (Soya), and Pap
(Ogi) through a modeled intestine. The study employed experimental and Computational …

Some glycoside drugs can be transported through intestinal glucose transporters (IGTs). The
surfactants used in oral drug preparations can affect the function of transporter proteins. This …

Background The levels of brain tetrahydrobiopterin (BH4), a coenzyme of tryptophan
hydroxylase and tyrosine hydroxylase, regulate the rates of monoamine synthesis, including …

Background Rhabdomyolysis is a potentially life-threatening disease caused by melting or
necrosis of skeletal muscle cells and leakage of muscle components into the bloodstream. It …

抄録 薬物トランスポーターは, 多様な薬物を基質として認識し, 生体内において血中滞留性や組織
分布の決定要因として重要な役割を果たす. 本稿では, 筆者らの研究成果も含めて …