TYROBP (also known as DAP12 or KARAP) is a transmembrane adaptor protein initially
described as a receptor-activating subunit component of natural killer (NK) cells. TYROBP is …

Alzheimer's disease (AD) is characterized by two major pathological lesions in the brain,
amyloid plaques and neurofibrillary tangles (NFTs) composed mainly of amyloid-β (Aβ) …

The autophagy–lysosomal pathway plays a critical role in intracellular clearance and
metabolic homeostasis. While neuronal autophagy is known to participate in the …

Tauopathies are a heterogenous class of diseases characterized by cellular accumulation of
aggregated tau and include diseases such as Alzheimer's disease (AD), progressive …

Genetic and genomic studies have advanced our knowledge of inherited Parkinson's
disease (PD), however, the etiology and pathophysiology of idiopathic PD remain unclear …

Neurofibrillary tangles (NFTs) composed of hyperphosphorylated and misfolded tau protein
are a pathological hallmark of Alzheimer's disease and other tauopathy conditions. Tau is …

Several genetic variants of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2)
have been shown to increase the risk of developing Alzheimer's disease (AD) supporting a …

Introduction The inositol polyphosphate‐5‐phosphatase D (INPP5D) gene encodes a dual‐
specificity phosphatase that can dephosphorylate both phospholipids and phosphoproteins …

Cellular accumulation of aggregated forms of the protein tau is a defining feature of so-
called tauopathies such as Alzheimer's disease, progressive supranuclear palsy, and …

As an essential component of our innate immune system, the complement system is
responsible for our defense against pathogens. The complement cascade has complex …