The main proteases (Mpro), also termed 3‐chymotrypsin‐like proteases (3CLpro), are a
class of highly conserved cysteine hydrolases in β‐coronaviruses. Increasing evidence has …

Since its outbreak in late 2019, the COVID-19 pandemic has drawn enormous attention
worldwide as a consequence of being the most disastrous infectious disease in the past …

SARS-CoV-2 is the causative agent of COVID-19. The main viral protease (M pro) is an
attractive target for antivirals. The clinically approved drug nirmatrelvir and the clinical …

Impedimetric wearable sensors are a promising strategy for determining the loss of water
content (LWC) from leaves because they can afford on-site and nondestructive quantification …

The role of dimer formation for the onset of catalytic activity of SARS-CoV-2 main protease
(MProWT) was assessed using a predominantly monomeric mutant (MProM). Rates of …

The main protease of SARS-CoV-2 (Mpro) is an important target for developing COVID-19
therapeutics. Recent work has highlighted Mpro's susceptibility to undergo redox-associated …

The monomeric catalytic domain (residues 1–199) of SARS-CoV-2 main protease (MPro1-
199) fused to 25 amino acids of its flanking nsp4 region mediates its autoprocessing at the …

The COVID-19 pandemic is a stark reminder that a barren global antiviral pipeline has grave
humanitarian consequences. Future pandemics could be prevented by accessible, easily …

In addition to its essential role in viral polyprotein processing, the SARS-CoV-2 3C-like
protease (3CLpro) can cleave human immune signaling proteins, like NF-κB Essential …

SARS-CoV-2, a human coronavirus, is the causative agent of the COVID-19 pandemic. Its
genome is translated into two large polyproteins subsequently cleaved by viral papain-like …