A review of liposomes as a drug delivery system: current status of approved products, regulatory environments, and future perspectives

P Liu, G Chen, J Zhang - Molecules, 2022 - mdpi.com
Liposomes have been considered promising and versatile drug vesicles. Compared with
traditional drug delivery systems, liposomes exhibit better properties, including site …

Hyperlipidemia and hypothyroidism

X Su, H Peng, X Chen, X Wu, B Wang - Clinica Chimica Acta, 2022 - Elsevier
Hypothyroidism is closely associated with increased serum total cholesterol (TC), low-
density lipoprotein cholesterol (LDL-C) and triglyceride (TG). The thyroid gland plays an …

The novel function of bexarotene for neurological diseases

Y Liu, P Wang, G Jin, P Shi, Y Zhao, J Guo, Y Yin… - Ageing Research …, 2023 - Elsevier
Bexarotene, a retinoid X receptor (RXR) agonist, is approved by FDA to treat cutaneous T-
cell lymphoma. However, it has also demonstrated promising therapeutic potential for …

Advances of stable isotope technology in food safety analysis and nutrient metabolism research

W Xia, X Fang, Y Gao, W Wu, Y Han, R Liu, H Yang… - Food Chemistry, 2023 - Elsevier
Food quality, safety, and the regulatory metabolism of food nutrients in cells are primary
factors in determining human health. However, residues of undesirable or hazardous …

Early to sustained impacts of lethal radiation on circulating miRNAs in a minipig model

N Chakraborty, GP Holmes-Hampton, A Gautam… - Scientific Reports, 2023 - nature.com
Early diagnosis of lethal radiation is imperative since its intervention time windows are
considerably short. Hence, ideal diagnostic candidates of radiation should be easily …

Intratumoral restoration of miR-137 plus cholesterol favors homeostasis of the miR-137/coactivator p160/AR axis and negatively modulates tumor progression in …

R Pimenta, CM Mioshi, GL Gonçalves… - International journal of …, 2023 - mdpi.com
MicroRNAs (miRNAs) have gained a prominent role as biomarkers in prostate cancer (PCa).
Our study aimed to evaluate the potential suppressive effect of miR-137 in a model of …

[HTML][HTML] Novel insights into the pathological development of dyslipidemia in patients with hypothyroidism

X Su, X Chen, H Peng, J Song, B Wang… - Bosnian journal of basic …, 2022 - ncbi.nlm.nih.gov
According to the previous reports, hypothyroidism has been shown to be strongly correlated
with increased circulating concentrations of total cholesterol, low-density lipoprotein …

[HTML][HTML] LncHLEF promotes hepatic lipid synthesis through miR-2188-3p/GATA6 axis and encoding peptides and enhances intramuscular fat deposition via exosome

Y Guo, W Tian, D Wang, L Yang, Z Wang, X Wu… - International Journal of …, 2023 - Elsevier
Long noncoding RNAs (lncRNAs) have emergingly been implicated in mammalian lipid
metabolism. However, their biological functions and regulatory mechanisms underlying …

Active and allosteric site binding MM-QM studies of Methylidene tetracyclo derivative in PCSK9 protein intended to make a safe antilipidemic agent

N Irfan, P Vaithyanathan, H Anandaram… - Journal of …, 2023 - Taylor & Francis
Interaction of low-density lipoprotein receptors with proprotein convertase subtilisin/kexin
type 9 (PCSK9) plays a vital part in causing atherosclerosis. It is the hidden precursor of …

Differences in Bacterial Small RNAs in Stool Samples from Hypercholesterolemic and Normocholesterolemic Subjects

C Morales, R Arias-Carrasco… - International Journal of …, 2023 - mdpi.com
Cholesterol metabolism is important at the physiological level as well as in several diseases,
with small RNA being an element to consider in terms of its epigenetic control. Thus, the aim …