Current strategies of antiviral drug discovery for COVID-19

M Mei, X Tan - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
SARS-CoV-2 belongs to the family of enveloped, single-strand RNA viruses known as
Betacoronavirus in Coronaviridae, first reported late 2019 in China. It has since been …

[HTML][HTML] Robust SARS-CoV-2 infection in nasal turbinates after treatment with systemic neutralizing antibodies

D Zhou, JFW Chan, B Zhou, R Zhou, S Li, S Shan… - Cell host & …, 2021 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is characterized by a burst
in the upper respiratory portal for high transmissibility. To determine human neutralizing …

Efficacy and safety of remdesivir in hospitalized Covid‐19 patients: systematic review and meta‐analysis including network meta‐analysis

HK Elsawah, MA Elsokary, MS Abdallah… - Reviews in medical …, 2021 - Wiley Online Library
Remdesivir is an antiviral agent that has shown broad‐spectrum activity, including against
severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Clinical trials investigating …

[HTML][HTML] The efficiency and safety of high-dose vitamin C in patients with COVID-19: a retrospective cohort study

D Gao, M Xu, G Wang, J Lv, X Ma, Y Guo… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Background: The inflammatory reaction is the main cause of acute respiratory distress
syndrome and multiple organ failure in patients with Coronavirus disease 2019, especially …

SARS-CoV-2 Nsp5 demonstrates two distinct mechanisms targeting RIG-I and MAVS to evade the innate immune response

Y Liu, C Qin, Y Rao, C Ngo, JJ Feng, J Zhao, S Zhang… - MBio, 2021 - Am Soc Microbiol
Newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a
global pandemic with astonishing mortality and morbidity. The high replication and …

Impact of COVID-19 on the liver and on the care of patients with chronic liver disease, hepatobiliary cancer, and liver transplantation: An updated EASL position paper

T Marjot, CS Eberhardt, T Boettler, LS Belli… - Journal of …, 2022 - Elsevier
The COVID-19 pandemic has presented a serious challenge to the hepatology community,
particularly healthcare professionals and patients. While the rapid development of safe and …

Clinical course and management of COVID-19 in the era of widespread population immunity

EA Meyerowitz, J Scott, A Richterman, V Male… - Nature Reviews …, 2024 - nature.com
The clinical implications of COVID-19 have changed since SARS-CoV-2 first emerged in
humans. The current high levels of population immunity, due to prior infection and/or …

Compassionate use of remdesivir in children with severe COVID-19

DL Goldman, ML Aldrich, SHF Hagmann… - …, 2021 - publications.aap.org
OBJECTIVES: Remdesivir shortens time to recovery in adults with severe coronavirus
disease 2019 (COVID-19), but its efficacy and safety in children are unknown. We describe …

Remdesivir and GS-441524 retain antiviral activity against Delta, Omicron, and other emergent SARS-CoV-2 variants

J Pitts, J Li, JK Perry, V Du Pont, N Riola… - Antimicrobial agents …, 2022 - Am Soc Microbiol
Genetic variation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
resulted in the emergence and rapid spread of multiple variants throughout the pandemic, of …

Remdesivir in Coronavirus Disease 2019 (COVID-19) treatment: a review of evidence

HXJ Lin, S Cho, V Meyyur Aravamudan, HY Sanda… - Infection, 2021 - Springer
COVID-19 is an infectious disease caused by a novel β-coronavirus, belonging to the same
subgenus as the Severe Acute Respiratory Syndrome (SARS) virus. Remdesivir, an …