Resistant hypertension (RH) is defined as above-goal elevated blood pressure (BP) in a
patient despite the concurrent use of 3 antihypertensive drug classes, commonly including a …

Due to the pharmacological activities of quinazoline and quinazolinone scaffolds, it has
aroused great interest in medicinal chemists for the development of new drugs or drug …

MicroRNAs (miRNAs) have been proven to be involved in cell metastasis and angiogenesis
by interaction with the target mRNAs. Evidence has been confirmed that miR-140-5p is a …

Over the years, studies have focused on the transcriptional regulation of oncogenesis. More
recently, a growing emphasis has been placed on translational control. The Ras and Akt …

Purpose We studied the safety, clinical activity, and pharmacokinetics (PK) of AG-013736,
an oral receptor tyrosine kinase inhibitor of vascular endothelial cell growth factor, platelet …

Anti-angiogenesis targeting VEGFR-2 has been considered as an important strategy for
cancer therapy. Ellagic acid is a naturally existing polyphenol widely found in fruits and …

BACKGROUND: Due to a dismal prognosis of advanced lung cancer, novel screening tools
and more effective treatments are clearly needed. Lately, an increasing number of tumour …

Mast cells (MCs) are well known for their neoplastic transformation in solitary and multiple
cutaneous mast cell tumours (MCTs), as well as visceral and systemic mastocytosis. Dogs …

With emerging trends in the incidence of cancer of various organ sites, additional
approaches are needed to control human malignancies. Intervention or prevention of cancer …

The C-terminal domain of the Dnmt3a de novo DNA methyltransferase (Dnmt3a-C) forms a
complex with the C-terminal domain of Dnmt3L, which stimulates its catalytic activity. We …