Role of C-reactive protein at sites of inflammation and infection

NR Sproston, JJ Ashworth - Frontiers in immunology, 2018 - frontiersin.org
C-reactive protein (CRP) is an acute inflammatory protein that increases up to 1,000-fold at
sites of infection or inflammation. CRP is produced as a homopentameric protein, termed …

Role of C‐reactive protein in diabetic inflammation

J Stanimirovic, J Radovanovic, K Banjac… - Mediators of …, 2022 - Wiley Online Library
Even though type 2 diabetes mellitus (T2DM) represents a worldwide chronic health issue
that affects about 462 million people, specific underlying determinants of insulin resistance …

[HTML][HTML] Glutathione: A Samsonian life-sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation

CA Labarrere, GS Kassab - Frontiers in Nutrition, 2022 - frontiersin.org
Many local and systemic diseases especially diseases that are leading causes of death
globally like chronic obstructive pulmonary disease, atherosclerosis with ischemic heart …

C-reactive protein and inflammation: conformational changes affect function

Y Wu, LA Potempa, D El Kebir, JG Filep - Biological chemistry, 2015 - degruyter.com
The prototypic acute-phase reactant C-reactive protein (CRP) has long been recognized as
a useful marker and gauge of inflammation. CRP also plays an important role in host …

Inflammatory risk factors, biomarkers and associated therapy in ischaemic stroke

CC Esenwa, MS Elkind - Nature Reviews Neurology, 2016 - nature.com
Proinflammatory conditions, including acute and chronic infections, have been associated
with an increased risk of stroke. The risk of stroke is increased by both the acute and chronic …

Elevated C-reactive protein in the diagnosis, prognosis, and cause of cancer

KH Allin, BG Nordestgaard - Critical reviews in clinical laboratory …, 2011 - Taylor & Francis
The aim of this review is to summarize present evidence of an association between
circulating levels of C-reactive protein (CRP) and cancer risk, and to evaluate whether …

C‐reactive protein as an effector molecule in Covid‐19 pathogenesis

JA Mosquera‐Sulbaran, A Pedreañez… - Reviews in medical …, 2021 - Wiley Online Library
The current pandemic caused by SARS‐CoV‐2 virus infection is known as Covid‐19
(coronavirus disease 2019). This disease can be asymptomatic or can affect multiple organ …

How C-reactive protein structural isoforms with distinctive bioactivities affect disease progression

IM Rajab, PC Hart, LA Potempa - Frontiers in immunology, 2020 - frontiersin.org
C-reactive protein (CRP) is a widely known, hepatically synthesized protein whose blood
levels change rapidly and pronouncedly in response to any tissue damaging event …

Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites

D Braig, TL Nero, HG Koch, B Kaiser, X Wang… - Nature …, 2017 - nature.com
C-reactive protein (CRP) concentrations rise in response to tissue injury or infection.
Circulating pentameric CRP (pCRP) localizes to damaged tissue where it leads to …

Dissociation of C-reactive protein localizes and amplifies inflammation: evidence for a direct biological role of C-reactive protein and its conformational changes

JD McFadyen, J Kiefer, D Braig, J Loseff-Silver… - Frontiers in …, 2018 - frontiersin.org
C-reactive protein (CRP) is a member of the pentraxin superfamily that is widely recognized
as a marker of inflammatory reactions and cardiovascular risk in humans. Recently, a …