Genetic variation of the Plasmodium falciparum circumsporozoite protein in parasite isolates from Homabay County in Kenya
The Plasmodium falciparum Circumsporozoite Protein (PfCSP) has been used in
developing the RTS, S, and R21 malaria vaccines. However, genetic polymorphisms within …
developing the RTS, S, and R21 malaria vaccines. However, genetic polymorphisms within …
First Phase 1b, single-center, age de-escalation trial of the P. falciparum blood-stage malaria vaccine candidate RH5.1/Matrix-M™: a delayed boost regimen induces …
SE Silk, WF Kalinga, J Salkeld, IM Mtaka, S Ahmed… - medRxiv, 2024 - medrxiv.org
Background RH5. 1 is a soluble protein vaccine candidate for blood-stage Plasmodium
falciparum malaria, previously trialed in healthy UK adults in combination with AS01B …
falciparum malaria, previously trialed in healthy UK adults in combination with AS01B …
Baseline malaria infection status and RTS, S/AS01E malaria vaccine efficacy
M Juraska, AM Early, L Li, SF Schaffner, M Lievens… - medRxiv, 2023 - medrxiv.org
Background The only licensed malaria vaccine, RTS, S/AS01E, confers moderate protection
against symptomatic disease. Because many malaria infections are asymptomatic, we …
against symptomatic disease. Because many malaria infections are asymptomatic, we …
[HTML][HTML] Cross-reactivity of rPvs48/45, a recombinant Plasmodium vivax protein, with sera from Plasmodium falciparum endemic areas of Africa
S Balam, K Miura, I Ayadi, D Konaté, NC Incandela… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Background: Ps48/45, a Plasmodium gametocyte surface protein, is a promising candidate
for malaria transmission-blocking (TB) vaccine. Due to its relevance for a multispecies …
for malaria transmission-blocking (TB) vaccine. Due to its relevance for a multispecies …
[HTML][HTML] A Potent Kalihinol Analogue Disrupts Apicoplast Function and Vesicular Trafficking in P. falciparum Malaria
Z Chahine, S Abel, T Hollin, JH Chung, GL Barnes… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Here we report the discovery of MED6-189, a new analogue of the kalihinol family of
isocyanoterpene (ICT) natural products. MED6-189 is effective against drug-sensitive and …
isocyanoterpene (ICT) natural products. MED6-189 is effective against drug-sensitive and …
Fractional dosing to improve vaccination coverage, vaccine hesitancy, and cost-effectiveness in Africa: a systematic review
A Yacouba, S Brah, M Daou, AK Andia, A Ibrahim… - medRxiv, 2023 - medrxiv.org
Background. The major challenges of vaccination programs are notably coverage in the
target population, vaccine hesitancy, and cost-effectiveness. A vaccination strategy with …
target population, vaccine hesitancy, and cost-effectiveness. A vaccination strategy with …
Vaccination with fractional doses: promise or illusion?
F Ntoumi, PG Kremsner - The Lancet Infectious Diseases, 2022 - thelancet.com
In The Lancet Infectious Diseases, Aaron M Samuels and colleagues1 assessed the efficacy
of fractional RTS, S/AS01E (hereafter referred to as RTS, S) vaccines doses against malaria …
of fractional RTS, S/AS01E (hereafter referred to as RTS, S) vaccines doses against malaria …
Stalled malaria control–root causes and possible remedies
JW Hargrove, GA Vale - medRxiv, 2022 - medrxiv.org
Background Malaria control has been stalled for some years in many African countries. We
suggest reasons for the stalling, and ways of remedying the situation. Methods We analyse …
suggest reasons for the stalling, and ways of remedying the situation. Methods We analyse …
Immunogenicity and Protection of the mXCL1-PyCSP Fusion Protein Prime-and-Trap DNA Vaccine in a Murine Malaria Immunization/Challenge Model
K Boey - 2024 - search.proquest.com
Malaria is a life-threatening parasitic disease caused by Plasmodium spp. and is transmitted
by female Anopheles spp. mosquitoes. Annually, there are nearly 250 million cases …
by female Anopheles spp. mosquitoes. Annually, there are nearly 250 million cases …
Unravelling the predictors of vaccine defaults in Southern Ghana: Evidence from the Malaria RTSS vaccine implementation trial program in the Cape Coast Metropolis
VB Bediako, JA Ackah, TJ Yankey, J Okyere… - 2024 - researchsquare.com
Malaria has been a severe global and public health concern for the last couple of decades.
Ghana, like many other countries in sub–Saharan Africa, is most affected by the disease …
Ghana, like many other countries in sub–Saharan Africa, is most affected by the disease …