Emerging principles of cytokine pharmacology and therapeutics
Cytokines are secreted signalling proteins that play essential roles in the initiation,
maintenance and resolution of immune responses. Although the unique ability of cytokines …
maintenance and resolution of immune responses. Although the unique ability of cytokines …
Decoding type I and III interferon signalling during viral infection
EV Mesev, RA LeDesma, A Ploss - Nature microbiology, 2019 - nature.com
Interferon (IFN)-mediated antiviral responses are central to host defence against viral
infection. Despite the existence of at least 20 IFNs, there are only three known cell surface …
infection. Despite the existence of at least 20 IFNs, there are only three known cell surface …
Antitumour actions of interferons: implications for cancer therapy
BS Parker, J Rautela, PJ Hertzog - Nature Reviews Cancer, 2016 - nature.com
The interferons (IFNs) are a family of cytokines that protect against disease by direct effects
on target cells and by activating immune responses. The production and actions of IFNs are …
on target cells and by activating immune responses. The production and actions of IFNs are …
Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion
Cholesterol 25-hydroxylase (CH25H) is an interferon (IFN)-stimulated gene that shows
broad antiviral activities against a wide range of enveloped viruses. Here, using an IFN …
broad antiviral activities against a wide range of enveloped viruses. Here, using an IFN …
EASL Clinical Practice Guidelines on hepatitis delta virus
Hepatitis D virus (HDV) is a defective virus that requires the hepatitis B virus to complete its
life cycle and cause liver damage in humans. HDV is responsible for rare acute and chronic …
life cycle and cause liver damage in humans. HDV is responsible for rare acute and chronic …
The immunogenetics of psoriasis: a comprehensive review
JL Harden, JG Krueger, AM Bowcock - Journal of autoimmunity, 2015 - Elsevier
Psoriasis vulgaris is a common, chronic inflammatory skin disease with a complex etiology
involving genetic risk factors and environmental triggers. Here we describe the many known …
involving genetic risk factors and environmental triggers. Here we describe the many known …
A positive feedback amplifier circuit that regulates interferon (IFN)-stimulated gene expression and controls type I and type II IFN responses
A Michalska, K Blaszczyk, J Wesoly… - Frontiers in …, 2018 - frontiersin.org
Interferon (IFN)-I and IFN-II both induce IFN-stimulated gene (ISG) expression through Janus
kinase (JAK)-dependent phosphorylation of signal transducer and activator of transcription …
kinase (JAK)-dependent phosphorylation of signal transducer and activator of transcription …
Interferon-λ: immune functions at barrier surfaces and beyond
When type III interferon (IFN-λ; also known as interleukin-28 [IL-28] and IL-29) was
discovered in 2003, its antiviral function was expected to be analogous to that of type I IFNs …
discovered in 2003, its antiviral function was expected to be analogous to that of type I IFNs …
Canonical and non-canonical aspects of JAK–STAT signaling: lessons from interferons for cytokine responses
A Majoros, E Platanitis, E Kernbauer-Hölzl… - Frontiers in …, 2017 - frontiersin.org
Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signal
transduction mediates cytokine responses. Canonical signaling is based on STAT tyrosine …
transduction mediates cytokine responses. Canonical signaling is based on STAT tyrosine …
Guarding the frontiers: the biology of type III interferons
A Wack, E Terczyńska-Dyla, R Hartmann - Nature immunology, 2015 - nature.com
Type III interferons (IFNs) or IFN-λs regulate a similar set of genes as type I IFNs, but
whereas type I IFNs act globally, IFN-λs primarily target mucosal epithelial cells and protect …
whereas type I IFNs act globally, IFN-λs primarily target mucosal epithelial cells and protect …