Transcription is epigenetically regulated by the orchestrated function of chromatin-binding
proteins that tightly control the expression of master transcription factors, effectors, and …

Chromatin organization and transcriptional profiles undergo tremendous reordering during
senescence. However, uncovering the regulatory mechanisms between chromatin …

Abstract p300/CBP histone acetyltransferases (HAT) are critical transcription coactivators
involved in multiple cellular activities. They act at multiple levels in non-small cell lung …

We previously reported the neuroprotective effects of icariin in rat cortical neurons. Here, we
present a study on icariin's anti-aging effect in 24-month aged mice by treating them with a …

Next generation antiandrogens such as enzalutamide (Enz) are effective initially for the
treatment of castration-resistant prostate cancer (CRPC). However, the disease often …

Atrial fibrosis induced by aging is one of the main causes of atrial fibrillation (AF), but the
potential molecular mechanism is not clear. Acetyltransferase p300 participates in the …

Cellular senescence is the irreversible cell cycle arrest in response to DNA damage.
Because senescent cells accumulate with age and contribute to chronic inflammation, they …

Mammalian aging is characterized by the progressive loss of tissue function and increased
risk for disease. Accumulation of senescent cells in aging tissues partly contributes to this …

The aging proteostasis decline manifests in a failure of aging cells and organisms to
properly respond to proteotoxic challenges. This proteostasis collapse has long been …

Epigenetic alterations are a key hallmark of aging but have been limitedly explored in
tissues. Here, using naturally aged murine liver as a model and extending to other quiescent …