Aging has become one of the fastest-growing research topics in biology. However, exactly
how the aging process occurs remains unknown. Epigenetics plays a significant role, and …

Prostate cancer is one of the most common malignant diseases in men, and it contributes
significantly to the increased mortality rate in men worldwide. This study aimed to review the …

Background Increasing life expectancy but also healthspan seems inaccessible as of yet but
it may become a reality in the foreseeable future. To extend lifespan, it is essential to unveil …

The development of interventions aimed at improving healthspan is one of the priority tasks
for the academic and public health authorities. It is also the main objective of a novel branch …

Senescence is a fate-determined state, accompanied by reorganization of heterochromatin.
Although lineage-appropriate genes can be temporarily repressed through facultative …

Pregnancy causes a series of cellular and molecular changes in mammary epithelial cells
(MECs) of female adults. In addition, pregnancy can also modify the predisposition of rodent …

Cardiovascular disease is the leading cause of accelerated as well as chronological aging-
related human morbidity and mortality worldwide. Genetic, immunologic, unhealthy lifestyles …

A major stress response influenced by microRNAs (miRNAs) is senescence, a state of
indefinite growth arrest triggered by sublethal cell damage. Here, through bioinformatic …

Chemical discovery efforts commonly target individual protein domains. Many proteins,
including the EP300/CBP histone acetyltransferases (HATs), contain several targetable …

Aging is an inexorable event occurring universally for all organisms characterized by the
progressive loss of cell function. However, less is known about the key events occurring …