Mammalian aging is characterized by the progressive loss of tissue integrity and function
manifesting in ill health and increased risk for developing multiple chronic conditions …

Protein N-ε-lysine acetylation is is an important post-translational modification that plays
critical roles in the regulation of many cellular processes. A role for this modification in the …

Aging is a complex process influenced by many environmental and genetic factors. Multiple
age-regulating genes have been identified in humans and model organisms. However, how …

Many aging diseases such as cancer, cardiovascular disease, and neurodegenerative
disorders are characterized, at the molecular level by an alteration of gene expression …

Chromatin regulation and alternative splicing are both critical mechanisms guiding gene
expression. Studies have demonstrated that histone modifications can influence alternative …

Cellular senescence has recently been recognized as a hallmark of cancer, reflecting its
association with aging and inflammation, its role as a response to deregulated proliferation …

The unusual SASPects | Nature Reviews Molecular Cell Biology Skip to main content Thank
you for visiting nature.com. You are using a browser version with limited support for CSS. To …

Environ 30% des cancers humains ont une mutation gain de fonction dans l'oncogène RAS,
menant à une prolifération cellulaire accrue et une expansion clonale. Cependant, il est …

Cellular senescence is regarded as an irreversible cell cycle arrest associated with tissue
aging and its functional decline. A senescence response is also evoked by oncogenic and …

Lung cancer is the principal cause of oncogenic mortality, non-small cell lung cancer
(NSCLC) being the most common form. Although different treatments are available …