Development and validation of an interpretable machine learning model—Predicting mild cognitive impairment in a high-risk stroke population

FJ Yan, XH Chen, XQ Quan, LL Wang… - Frontiers in Aging …, 2023 - frontiersin.org
Background Mild cognitive impairment (MCI) is considered a preclinical stage of Alzheimer's
disease (AD). People with MCI have a higher risk of developing dementia than healthy …

Estradiol improves behavior in FAD transgenic mice that express APOE3 but not APOE4 after ovariectomy

D Balu, AC Valencia-Olvera, A Deshpande… - Frontiers in …, 2024 - frontiersin.org
Increasing evidence suggests that female individuals have a higher Alzheimer's disease
(AD) risk associated with post-menopausal loss of circulating estradiol (E2). However …

[HTML][HTML] A cingulate-hippocampal circuit mediates early depressive-like behavior in the mouse model of Alzheimer disease

Y Chen, H Peng, K Zhuang, W Xie, C Li, M Chen, J Xue… - Iscience, 2024 - cell.com
Depressive symptoms usually precede the cognitive decline in Alzheimer disease (AD) and
worsen the clinical outcome. However, the neural circuitry mediating early emotional …

Towards a Deeper Understanding: Utilizing Machine Learning to Investigate the Association between Obesity and Cognitive Decline—A Systematic Review

I Veneziani, A Grimaldi, A Marra, E Morini… - Journal of Clinical …, 2024 - mdpi.com
Background/Objectives: Several studies have shown a relation between obesity and
cognitive decline, highlighting a significant global health challenge. In recent years, artificial …

Harnessing Passive Pulsatile Shear Stress for Alzheimer's Disease Prevention and Intervention

JA Adams, A Uryash, JR Lopez - Journal of Alzheimer's …, 2024 - content.iospress.com
Alzheimer's disease (AD) affects more than 40 million people worldwide and is the leading
cause of dementia. This disease is a challenge for both patients and caregivers and puts a …

Alzheimer's Disease in Lebanon: Exploring Genetic and Environmental Risk Factors—A Comprehensive Review

M Khaled, H Al-Jamal, L Tajer… - Journal of Alzheimer's …, 2024 - content.iospress.com
Alzheimer's disease (AD) is a neurodegenerative condition that displays a high prevalence
in Lebanon causing a local burden in healthcare and socio-economic sectors. Unfortunately …

[HTML][HTML] Impacts of education level on Montreal Cognitive Assessment and saccades in community residents from Western China

H Li, A Peng, W Lai, J Wu, S Ji, D Hu, S Chen… - Clinical …, 2024 - Elsevier
Objectives This cross-sectional study sought to evaluate the effectiveness of the Montreal
Cognitive Assessment (MoCA) and saccade in discerning the cognitive function levels …

Investigating the Impact of Tea Consumption on Cognitive Function and Exploring Tea-Genetic Interactions in Older Adults Aged 65–105 Years: Findings from the …

L Yu, M Yang, KX Ye, C Li, M Zou, J Wang… - The Journal of …, 2024 - Springer
Background As the global population ages, cognitive impairment (CI) becomes more
prevalent. Tea has been one of the most popular drinks in the world. Several studies have …

Biobased nanoemulsions for targeted drug delivery to treat dementia and aging

JS D'Arrigo - Aging Pathobiology and Therapeutics, 2023 - antpublisher.com
Early changes in cerebrovascular hemodynamics and endothelial function can contribute to
altered cognitive function and systemic vascular stiffness later in life. Accordingly, vascular …

Threshold and combined effects of heavy metals on the risk of phenotypic age acceleration among US adults

Y Liu, Z Jin, S Fu - BioMetals, 2024 - Springer
Accumulation of heavy metals in the body has been shown to affect the phenotypic age
(PhenoAge). However, the combined and threshold effects of blood heavy metals on the risk …