An overview of JAK/STAT pathways and JAK inhibition in alopecia areata

M Lensing, A Jabbari - Frontiers in immunology, 2022 - frontiersin.org
Alopecia Areata (AA) is a common autoimmune disease characterized by non-scarring hair
loss ranging from patches on the scalp to complete hair loss involving the entire body …

The role of serum Th1, Th2, and Th17 cytokines in patients with alopecia areata: clinical implications

A Waśkiel-Burnat, M Osińska, A Salińska, L Blicharz… - Cells, 2021 - mdpi.com
Alopecia areata is a type of non-scarring hair loss. The dysregulation of numerous systemic
Th1 (IL-2, IFN-γ, TNF, IL-12, and IL-18), Th2 (IL-4, IL-5, IL-6, IL-9, IL-10, IL-13, IL-17E, IL-31 …

Evaluating the therapeutic potential of ritlecitinib for the treatment of alopecia areata

HA Ramírez-Marín, A Tosti - Drug design, development and …, 2023 - Taylor & Francis
Alopecia areata (AA) is an autoimmune condition that causes patchy hair loss, affecting up
to 147 million people globally. Currently, there are no treatments approved by US Food and …

Inhibition of T-cell activity in alopecia areata: Recent developments and new directions

T Passeron, B King, J Seneschal, M Steinhoff… - Frontiers in …, 2023 - frontiersin.org
Alopecia areata (AA) is an autoimmune disease that has a complex underlying
immunopathogenesis characterized by nonscarring hair loss ranging from small bald …

Interleukin‐15 and Tumor Necrosis Factor‐α in Iraqi Patients with Alopecia Areata

ZA Kamil, GA Abdullah… - Dermatology Research and …, 2023 - Wiley Online Library
Background. Alopecia areata (AA) is a common form of noncicatricial hair loss of unknown
cause, affecting 0.1‐0.2% of the general population. Most evidence supports the hypothesis …

Interleukin-15 is a hair follicle immune privilege guardian

T Suzuki, J Chéret, FS Dinelli, A Rajabi-Estarabadi… - Journal of …, 2024 - Elsevier
The autoimmunity-promoting cytokine, Interleukin-15 (IL-15), is often claimed to be a key
pathogenic cytokine in alopecia areata (AA). Yet, rhIL-15 promotes human hair follicle (HF) …

IL-15 prolongs anagen, stimulates proliferation, and suppresses apoptosis in the hair matrix of human scalp hair follicles

T Suzuki, F Scala, DL Demetrius… - The Journal of …, 2024 - pubmed.ncbi.nlm.nih.gov
IL-15 Prolongs Anagen, Stimulates Proliferation, and Suppresses Apoptosis in the Hair Matrix of
Human Scalp Hair Follicles IL-15 Prolongs Anagen, Stimulates Proliferation, and Suppresses …

[HTML][HTML] 斑秃免疫学机制研究进展

王敏, 王敏华 - Advances in Clinical Medicine, 2024 - hanspub.org
斑秃是一种突发的炎症性, 非瘢痕性的脱发性疾病, 临床表现为斑片状脱发, 全部头发脱落,
全身毛发的脱落. 本病具有自限性, 但易复发, 当前治疗效果的数据有限. 目前斑秃的发病机制 …

Secretome of Hypoxic Mesenchymal Stem Cells Improves Fluconazole-Induced Alopecia in Rats via Immunoregulatory Modulation of IL-15 and IFN-γ

CK Rahardja, SP Mulyani, A Putra - Biosaintifika: Journal of …, 2024 - journal.unnes.ac.id
Increased IL-15 and IFN-γ characterize fluconazole-related alopecia (FRA). The hypoxia
mesenchymal stem cell (hMSC) secretome has anti-inflammatory capabilities that can …

PENGARUH PEMBERIAN GEL TOPIKAL SECRETOME HIPOKSIA MESENCHYMAL STEM CELL (SH-MSCs) TERHADAP EKSPRESI GEN IL-15 DAN IFN-(Studi …

CK Rahardja - 2023 - repository.unissula.ac.id
Latar Belakang: Alopecia areata (AA) adalah kelainan rambut yang dimediasi imun. Terjadi
peningkatan eskpresi gen IL-15 dan IFN-γ pada penderita AA. Riset ini tujuannya guna …