Purpose This review provides an overview of the current challenges in oral targeted
antineoplastic drug (OAD) dosing and outlines the unexploited value of therapeutic drug …

Most of oral targeted therapies are tyrosine kinase inhibitors (TKIs). Oral administration
generates a complex step in the pharmacokinetics (PK) of these drugs. Inter-individual PK …

Computational oncology is a generic term that encompasses any form of computer-based
modelling relating to tumour biology and cancer therapy. Mathematical modelling can be …

There is accumulating evidence for potential benefits of therapeutic drug monitoring (TDM)
in the treatment of cancer with tyrosine kinase inhibitors (TKIs). Relationships between …

Therapeutic drug monitoring (TDM) is a fundamental tool when administering drugs that
have a limited dosage or high toxicity, which could endanger the lives of patients. To carry …

Pharmacometric methods have hugely benefited from progress in analytical and computer
sciences during the past decades, and play nowadays a central role in the clinical …

Sorafenib is the first multi‐kinase inhibitor (TKI) approved for the treatment of advanced
hepatocellular cancer (HCC) and metastatic renal cell cancer (RCC) and is increasingly …

Drug− drug interactions (DDIs) occur when a patient's response to the drug is modified by
administration or co‐exposure to another drug. The main cytochrome P 450 (CYP) enzyme …

Many drug molecules that are currently in the market suffer from short half-life, poor
absorption, low specificity, rapid degradation, and resistance development. The design and …

Detecting chemical and biological molecules that indicate diseases is a prerequisite
technology for the efficient diagnoses and treatment of aging and diseases in living …