Omicron genetic and clinical peculiarities that may overturn SARS-CoV-2 pandemic: a literature review
The Coronavirus disease 2019 (COVID-19) pandemic poses a great threat to global public
health. The original wild-type strain of severe acute respiratory syndrome coronavirus 2 …
health. The original wild-type strain of severe acute respiratory syndrome coronavirus 2 …
Mutation informatics: SARS-CoV-2 receptor-binding domain of the spike protein
S Verma, VM Patil, MK Gupta - Drug Discovery Today, 2022 - Elsevier
Highlights•Mutation informatics study on RBD of SARS-CoV-2 variants.•Discussion of small
molecules targeting the RBD/ACE2 interface.•Ideation to design novel inhibitors against wild …
molecules targeting the RBD/ACE2 interface.•Ideation to design novel inhibitors against wild …
Omicron (B. 1.1. 529)-A new heavily mutated variant: Mapped location and probable properties of its mutations with an emphasis on S-glycoprotein
Abstract Omicron, another SARS-CoV-2 variant, has been recorded and reported as a VoC.
It has already spread across> 30 countries and is a highly mutated variant. We tried to …
It has already spread across> 30 countries and is a highly mutated variant. We tried to …
The impact of D614G mutation of SARS-COV-2 on the efficacy of anti-viral drugs: A comparative molecular docking and molecular dynamics study
D614G is one of the most reported mutations in the spike protein of SARS-COV-2 that has
altered some crucial characteristics of coronaviruses, such as rate of infection and binding …
altered some crucial characteristics of coronaviruses, such as rate of infection and binding …
Molecular dynamics simulations highlight the altered binding landscape at the spike-ACE2 interface between the Delta and Omicron variants compared to the SARS …
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B. 1.1. 529 variant
(Omicron), represents a significant deviation in genetic makeup and function compared to …
(Omicron), represents a significant deviation in genetic makeup and function compared to …
Landscape of molecular crosstalk between SARS-CoV-2 infection and cardiovascular diseases: emphasis on mitochondrial dysfunction and immune-inflammation
S Dai, T Cao, H Shen, X Zong, W Gu, H Li… - Journal of Translational …, 2023 - Springer
Abstract Background SARS-CoV-2, the pathogen of COVID-19, is a worldwide threat to
human health and causes a long-term burden on the cardiovascular system. Individuals with …
human health and causes a long-term burden on the cardiovascular system. Individuals with …
Significance of the RBD mutations in the SARS-CoV-2 omicron: from spike opening to antibody escape and cell attachment
We computationally investigated the role of the omicron RBD mutations on its structure and
interactions with the surrounding domains in the spike trimer as well as with ACE2. Our …
interactions with the surrounding domains in the spike trimer as well as with ACE2. Our …
Antigenic cross-reactivity between SARS-CoV-2 S1-RBD and its receptor ACE2
YC Lai, YW Cheng, CH Chao, YY Chang… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging virus
responsible for the ongoing COVID-19 pandemic. SARS-CoV-2 binds to the human cell …
responsible for the ongoing COVID-19 pandemic. SARS-CoV-2 binds to the human cell …
Correlation between in vitro neutralization assay and serological tests for protective antibodies detection
MA Bonifacio, R Laterza, A Vinella, A Schirinzi… - International Journal of …, 2022 - mdpi.com
Serological assays are useful in investigating the development of humoral immunity against
SARS-CoV-2 in the context of epidemiological studies focusing on the spread of protective …
SARS-CoV-2 in the context of epidemiological studies focusing on the spread of protective …
Pharmacological therapies and drug development targeting SARS-CoV-2 infection
The development of therapies for SARS-CoV-2 infection, based on virus biology and
pathology, and of large-and small-scale randomized controlled trials, have brought forward …
pathology, and of large-and small-scale randomized controlled trials, have brought forward …