The Genetically Informed Neurobiology of Addiction (GINA) model
Addictions are heritable and unfold dynamically across the lifespan. One prominent
neurobiological theory proposes that substance-induced changes in neural circuitry promote …
neurobiological theory proposes that substance-induced changes in neural circuitry promote …
Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals
Problematic alcohol use (PAU), a trait that combines alcohol use disorder and alcohol-
related problems assessed with a questionnaire, is a leading cause of death and morbidity …
related problems assessed with a questionnaire, is a leading cause of death and morbidity …
Opioid Trail: Tracking Contributions to Opioid Use Disorder from Host Genetics to the Gut Microbiome
Opioid use disorder (OUD) is a worldwide public health crisis with few effective treatment
options. Traditional genetics and neuroscience approaches have provided knowledge about …
options. Traditional genetics and neuroscience approaches have provided knowledge about …
[HTML][HTML] Multi-ancestry study of the genetics of problematic alcohol use in> 1 million individuals
Problematic alcohol use (PAU) is a leading cause of death and disability worldwide. To
improve our understanding of the genetics of PAU, we conducted a large cross-ancestry …
improve our understanding of the genetics of PAU, we conducted a large cross-ancestry …
Multi-trait genome-wide association analyses leveraging alcohol use disorder findings identify novel loci for smoking behaviors in the Million Veteran Program
Smoking behaviors and alcohol use disorder (AUD), both moderately heritable traits,
commonly co-occur in the general population. Single-trait genome-wide association studies …
commonly co-occur in the general population. Single-trait genome-wide association studies …
Identifying compounds to treat opiate use disorder by leveraging multi-omic data integration and multiple drug repurposing databases.
Genes influencing opioid use disorder (OUD) biology have been identified via genome-wide
association studies (GWAS), gene expression, and network analyses. These discoveries …
association studies (GWAS), gene expression, and network analyses. These discoveries …
Medical and genetic correlates of long-term buprenorphine treatment in the electronic health records
Despite the benefits associated with longer buprenorphine treatment duration (ie,> 180
days)(BTD) for opioid use disorder (OUD), retention remains poor. Research on the impact …
days)(BTD) for opioid use disorder (OUD), retention remains poor. Research on the impact …
Multi‐omics cannot replace sample size in genome‐wide association studies
The integration of multi‐omics information (eg, epigenetics and transcriptomics) can be
useful for interpreting findings from genome‐wide association studies (GWAS). It has been …
useful for interpreting findings from genome‐wide association studies (GWAS). It has been …
[HTML][HTML] Genome-wide analyses reveal shared genetic architecture and novel risk loci between opioid use disorder and general cognitive ability
Background Opioid use disorder (OUD), a serious health burden worldwide, is associated
with lower cognitive function. Recent studies have demonstrated a negative genetic …
with lower cognitive function. Recent studies have demonstrated a negative genetic …
[HTML][HTML] A review of the genomics of neonatal abstinence syndrome
E Yen, N Gaddis, L Jantzie, JM Davis - Frontiers in Genetics, 2023 - frontiersin.org
Neonatal abstinence syndrome (NAS) is a constellation of signs of withdrawal occurring
after birth following in utero exposure to licit or illicit opioids. Despite significant research and …
after birth following in utero exposure to licit or illicit opioids. Despite significant research and …