Colonic drug delivery can facilitate access to unique therapeutic targets and has the potential to enhance drug bioavailability whilst reducing off-target effects. Delivering drugs to …
The act of defaecation, although a ubiquitous human experience, requires the coordinated actions of the anorectum and colon, pelvic floor musculature, and the enteric, peripheral and …
C Fung, P Vanden Berghe - Cellular and Molecular Life Sciences, 2020 - Springer
The enteric nervous system (ENS) is an extensive network comprising millions of neurons and glial cells contained within the wall of the gastrointestinal tract. The major functions of …
Hirschsprung disease is defined by the absence of enteric neurons at the end of the bowel. The enteric nervous system (ENS) is the intrinsic nervous system of the bowel and regulates …
M Kim, G Heo, SY Kim - Nature Reviews Neuroscience, 2022 - nature.com
Eating and drinking generate sequential mechanosensory signals along the digestive tract. These signals are communicated to the brain for the timely initiation and regulation of …
Alterations in colonic motility are implicated in the pathophysiology of bowel disorders, but high-resolution manometry of human colonic motor function has revealed that our …
G Bazzocchi, S Turroni, MC Bulzamini, F D'Amico… - Scientific reports, 2021 - nature.com
After spinal cord injury (SCI), patients face many physical and psychological issues including intestinal dysfunction and comorbidities, strongly affecting quality of life. The gut …
S Das - International Journal of Pharmaceutics, 2021 - Elsevier
In case of colon-specific delivery of therapeutic agents through oral route, microbial/enzyme- triggered release approach has several advantages over other approaches due to unique …
Background The enteric nervous system (ENS) and the central nervous system (CNS) of mammals both contain integrative neural circuitry and similarities between them have led to …