Asthma is a heterogeneous chronic respiratory disease that impacts nearly 10% of the
population worldwide. While cellular senescence is a normal physiological process, the …

The musculoskeletal system supports the movement of the entire body and provides blood
production while acting as an endocrine organ. With aging, the balance of bone …

The decline in fertility in aging women, especially those with poor ovarian response (POR)
or primary ovarian insufficiency (POI), is a major concern for modern IVF centers. Fertility …

Many cancer patients experience serious cognitive problems related to their treatment,
which can greatly affect their quality of life. The molecular mechanisms of this cancer …

Chronic aging represents the leading risk factor for the vast majority of age-related diseases,
which together contribute to increased morbidities and elevated mortalities in late life …

Abstract Interleukin-6 (IL-6) is a pleiotropic cytokine and exerts its complex biological
functions mainly through three different signal modes, called cis-, trans-, and cluster …

Interconnected, fundamental aging processes are central to many illnesses and diseases.
Cellular senescence is a mechanism that halts the cell cycle in response to harmful stimuli …

Background β-Elemene (IUPAC name:(1 S, 2 S, 4 R)− 1-ethenyl-1-methyl-2, 4-bis (prop-1-
en-2-yl) cyclohexane), is a natural compound found in turmeric root. Studies have …

Spindle and kinetochore-associated complex subunit 3 (SKA3) is a microtubule-binding
subcomplex of the outer kinetochore, which plays a vital role in proper chromosomal …

Background Pre-mRNA processing factor 19 (PRPF19) is an E3 ligase that plays a crucial
role in repairing tumor-damaged cells and promoting cell survival. However, the predictive …