Patient and disease–specific induced pluripotent stem cells for discovery of personalized cardiovascular drugs and therapeutics

DT Paik, M Chandy, JC Wu - Pharmacological reviews, 2020 - ASPET
Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for
regenerative therapy, disease modeling, and drug discovery. iPSCs allow for the production …

High-sensitivity cardiac troponins in pediatric population

A Clerico, A Aimo, M Cantinotti - Clinical Chemistry and Laboratory …, 2022 - degruyter.com
Apparently healthy children often complain of chest pain, especially after physical exercise.
Cardiac biomarker levels are often measured, but the clinical relevance of these assays in …

Assessment of dexrazoxane as a cardioprotectant in doxorubicin-treated children with high-risk acute lymphoblastic leukaemia: long-term follow-up of a prospective …

SE Lipshultz, RE Scully, SR Lipsitz, SE Sallan… - The lancet …, 2010 - thelancet.com
Background Doxorubicin chemotherapy is associated with cardiomyopathy. Dexrazoxane
reduces cardiac damage during treatment with doxorubicin in children with acute …

Normative values of high-sensitivity cardiac troponin T and N-terminal pro-B-type natriuretic peptide in children and adolescents: a study from the CALIPER cohort

E Lam, V Higgins, L Zhang, MK Chan… - The Journal of …, 2021 - academic.oup.com
Background Cardiac troponin (cTn) and N-terminal pro-B-type natriuretic peptide (NT-
proBNP) are increasingly used clinically to evaluate and prognosticate acute myocardial …

Cardiac effects of antiretroviral therapy in HIV-negative infants born to HIV-positive mothers: NHLBI CHAART-1 (National Heart, Lung, and Blood Institute …

SE Lipshultz, WT Shearer, B Thompson… - Journal of the American …, 2011 - jacc.org
Objectives: The aim of this study was to investigate the possible effects of antiretroviral
therapy (ART) in utero on cardiac development and function in human immunodeficiency …

Cardiac troponin T in healthy full-term infants

J Karlén, M Karlsson, H Eliasson, AKE Bonamy… - Pediatric …, 2019 - Springer
In this prospective cohort study of healthy full-term infants, we hypothesized that high-
sensitivity cardiac troponin T (hs-cTnT) would be elevated in cord blood, compared with …

Cardiac injury biomarkers in paediatric age: Are we there yet?

AL Neves, T Henriques-Coelho, A Leite-Moreira… - Heart failure …, 2016 - Springer
The aim of this article is to evaluate the clinical utility of cardiac injury biomarkers in
paediatric age. In December 2015, a literature search was performed (PubMed access to …

Biomarkers of neonatal stress assessment: A prospective study

H Rouatbi, S Zigabe, E Gkiougki, L Vranken… - Early Human …, 2019 - Elsevier
Introduction Early diagnosis of perinatal asphyxia, the major cause of neonatal mortality and
morbidity, might be improved by the detection of neonatal stress biomarkers such as cardiac …

Troponin in newborns and pediatric patients

M Correale, L Nunno, R Ieva, M Rinaldi… - … Agents in Medicinal …, 2009 - ingentaconnect.com
Cardiac troponin represents a sensitive and specific marker of ischemic myocardial damage
in adult and neonatal populations. Cardiac function in neonates could be influenced by the …

Cardiac Biomarkers in Neonatology: BNP/NTproBNP, Troponin I/T, CKMB and Myoglobin, a systematic Review

RP Teixeira - PQDT-Global, 2017 - search.proquest.com
Abstract act Cardiac biomarkers play a central role in myocardial injury and heart failure in
adult patients however their clinical relevance in diagnosis and management in neonatology …