O-GlcNAcylation is a posttranslational modification that adds O-linked β-N-
acetylglucosamine (O-GlcNAc) to serine or threonine residues of many proteins. This protein …

Since the first formal description of Parkinson disease (PD) two centuries ago, our
understanding of this common neurodegenerative disorder has expanded at all levels of …

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Cross-frequency coupling (CFC) reflects (nonlinear) interactions between signals of different
frequencies. Evidence from both patient and healthy participant studies suggests that CFC …

The treatment of various central nervous system (CNS) diseases has been challenging,
despite the rapid development of several novel treatment approaches. The blood–brain …

When James Parkinson described the classical symptoms of the disease he could hardly
foresee the evolution of our understanding over the next two hundred years. Nowadays …

Increased risk of Parkinson disease with diabetes mellitus i... : Medicine Increased risk of
Parkinson disease with diabetes mellitus in a population-based study : Medicine Log in or …

Advances in molecular and structural and functional neuroimaging are rapidly expanding
the complexity of neurobiological understanding of Parkinson's disease (PD). This review …

Alpha-synuclein (aSyn) is considered a major culprit in Parkinson's disease (PD)
pathophysiology. However, the precise molecular function of the protein remains elusive …

Numerous clinical trials have provided evidence that health-related quality of life can be
substantially improved with early diagnosis and institution of exercise and other physical …