Kidney fibrosis, characterized by excessive deposition of extracellular matrix (ECM) that
leads to tissue scarring, is the final common outcome of a wide variety of chronic kidney …

Head and neck cancer (HNC) is malignant, genetically complex and difficult to treat and is
the sixth most frequent cancer, with tobacco, alcohol and human papillomavirus being major …

Physical activity has been known as an essential element to promote human health for
centuries. Thus, exercise intervention is encouraged to battle against sedentary lifestyle …

The low-density lipoprotein (LDL) receptor-related protein 2 (LRP2 or megalin) is
representative of the phylogenetically conserved subfamily of giant LDL receptor-related …

Diabetic kidney disease (DKD) is one of the most common and devastating complications of
diabetic mellitus, and its prevalence is rising worldwide. Klotho, an anti-aging protein, is …

The involvement of cardiovascular disease in cancer onset and development represents a
contemporary interest in basic science. It has been recognized, from the most recent …

Background Bone marrow-derived mesenchymal stem cells (BMSCs)-derived extracellular
vesicles (EVs) have shown potent anti-inflammatory function in various pathological …

Podocyte injury is a hallmark of glomerular diseases; however, the underlying mechanisms
remain unclear. B7-1 is increased in injured podocytes, but its intrinsic role is controversial …

The Wnt/β-catenin signaling pathway plays a crucial role in the development, tissue
homeostasis, angiogenesis, and carcinogenesis of cancer. Mutations and excessive …

The WNT/β‐catenin pathway is a master regulator of cardiac development and growth, and
its activity is low in healthy adult hearts. However, even this low activity is essential for …