Tissue development and homeostasis are controlled by mechanical cues. Perturbation of
the mechanical equilibrium triggers restoration of mechanostasis through changes in cell …

Single-pass transmembrane receptors (SPTMRs) represent a diverse group of integral
membrane proteins that are involved in many essential cellular processes, including signal …

Martini 3, the latest version of the widely used Martini force field for coarse-grained
molecular dynamics simulations, is a promising tool to investigate proteins in phospholipid …

The large family of C-type lectin (CLEC) receptors comprises carbohydrate-binding proteins
that require Ca2+ to bind a ligand. The prototypic receptor is the asialoglycoprotein receptor …

The impact of the EphA2 receptor on cancer malignancy hinges on the two different ways it
can be activated. EphA2 induces antioncogenic signaling after ligand binding, but ligand …

Background Cytokine receptor-like factor 2 (CRLF2) is a subunit of the receptor for thymic
stromal lymphopoietin (TSLP). A somatic mutation (insEIM) in the transmembrane domains …

Synthetic receptors are powerful tools for engineering mammalian cell-based devices.
These biosensors enable cell-based therapies to perform complex tasks such as regulating …

Group-specific component macrophage-activating factor (GcMAF) is the vitamin D3-binding
protein (DBP) deglycosylated at Thr420. The protein is believed to exhibit a wide range of …

Many growth factors and cytokines signal by binding to the extracellular domains of their
receptors and driving association and transphosphorylation of the receptor intracellular …

STARD1 moves cholesterol (CHOL) from the outer mitochondrial membrane (OMM) to the
inner membrane (IMM) in steroidogenic cells. This activity is integrated into CHOL trafficking …