Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in regenerative medicine

FJ Vizoso, N Eiro, S Cid, J Schneider… - International journal of …, 2017 - mdpi.com
Earlier research primarily attributed the effects of mesenchymal stem cell (MSC) therapies to
their capacity for local engrafting and differentiating into multiple tissue types. However …

Advances in extrusion 3D bioprinting: a focus on multicomponent hydrogel‐based bioinks

X Cui, J Li, Y Hartanto, M Durham… - Advanced …, 2020 - Wiley Online Library
Abstract 3D bioprinting involves the combination of 3D printing technologies with cells,
growth factors and biomaterials, and has been considered as one of the most advanced …

Exosomes derived from atorvastatin-pretreated MSC accelerate diabetic wound repair by enhancing angiogenesis via AKT/eNOS pathway

M Yu, W Liu, J Li, J Lu, H Lu, W Jia, F Liu - Stem cell research & therapy, 2020 - Springer
Background Mesenchymal stem cell (MSC)-derived exosomes emerge as promising
candidates for treating delayed wound healing in diabetes due to the promotion of …

[HTML][HTML] Articular fibrocartilage-Why does hyaline cartilage fail to repair?

AR Armiento, M Alini, MJ Stoddart - Advanced drug delivery reviews, 2019 - Elsevier
Once damaged, articular cartilage has a limited potential to repair. Clinically, a repair tissue
is formed, yet, it is often mechanically inferior fibrocartilage. The use of monolayer expanded …

Atorvastatin enhances the therapeutic efficacy of mesenchymal stem cells-derived exosomes in acute myocardial infarction via up-regulating long non-coding RNA …

P Huang, L Wang, Q Li, X Tian, J Xu, J Xu… - Cardiovascular …, 2020 - academic.oup.com
Aims Naturally secreted nanovesicles, known as exosomes, play important roles in stem cell-
mediated cardioprotection. We have previously demonstrated that atorvastatin (ATV) …

Advancing biomaterials of human origin for tissue engineering

FM Chen, X Liu - Progress in polymer science, 2016 - Elsevier
Biomaterials have played an increasingly prominent role in the success of biomedical
devices and in the development of tissue engineering, which seeks to unlock the …

[HTML][HTML] Harnessing tissue-derived extracellular vesicles for osteoarthritis theranostics

B Yin, J Ni, CE Witherel, M Yang, JA Burdick, C Wen… - Theranostics, 2022 - ncbi.nlm.nih.gov
Osteoarthritis (OA) is a prevalent chronic whole-joint disease characterized by low-grade
systemic inflammation, degeneration of joint-related tissues such as articular cartilage, and …

Tetraspanins in extracellular vesicle formation and function

Z Andreu, M Yáñez-Mó - Frontiers in immunology, 2014 - frontiersin.org
Extracellular vesicles (EVs) represent a novel mechanism of intercellular communication as
vehicles for intercellular transfer of functional membrane and cytosolic proteins, lipids, and …

The functions and clinical application potential of exosomes derived from adipose mesenchymal stem cells: a comprehensive review

P Hong, H Yang, Y Wu, K Li, Z Tang - Stem cell research & therapy, 2019 - Springer
Exosomes are extracellular membranous nanovesicles that mediate local and systemic
intercellular communication by transporting proteins or nucleic acids (DNA and RNA) into …

Preservation and storage stability of extracellular vesicles for therapeutic applications

A Jeyaram, SM Jay - The AAPS journal, 2018 - Springer
Abstract Recently, extracellular vesicles (EVs)—including exosomes, microvesicles, and
others—have attracted interest as cell-derived biotherapeutics and drug delivery vehicles for …