Malformations of cortical development are common causes of developmental delay and
epilepsy. Some patients have early, severe neurological impairment, but others have …

Migration toward pathology is the first critical step in stem cell engagement during
regeneration. Neural stem cells (NSCs) migrate through the parenchyma along …

Malformations of cortical development (MCD) represent a major cause of developmental
disabilities, severe epilepsy, and reproductive disadvantage. Genes that have been …

Summary 10· 5 million children worldwide are estimated to have active epilepsy. Over the
past 15 years, syndrome-oriented clinical and EEG diagnosis, and better aetiological …

Small G proteins play a central role in the organization of the secretory and endocytic
pathways. The majority of such small G proteins are members of the Rab family, which are …

Membrane trafficking pathways are essential for the viability and growth of cells, and play a
major role in the interaction of cells with their environment. In this At a Glance article and …

Genetic factors have an important role in the aetiology of mental retardation. However, their
contribution is often underestimated because in developed countries, severely affected …

Although membrane trafficking pathways are involved in basic cellular functions, the
evolutionally expanded number of their related family proteins suggests additional roles for …

Creating a functional cerebral cortex requires a series of complex and well-coordinated
developmental steps. These steps have evolved across species with the emergence of …

Apical–basal progenitor cell polarity establishes key features of the radial and laminar
architecture of the developing human cortex. The unique diversity of cortical stem cell …