Lysosome-related organelles (LROs) are a heterogeneous group of vesicles that share
various features with lysosomes, but are distinct in function, morphology, and composition …

Neuronal migration is a fundamental process that governs embryonic brain development. As
such, mutations that affect essential neuronal migration processes lead to severe brain …

The ADP ribosylation factors (Arfs) are a family of small, ubiquitously expressed and
evolutionarily conserved guanosine triphosphatases that are key regulators of vesicular …

Periventricular heterotopia (PH) occurs when collections of neurons lay along the lateral
ventricles or just beneath. Human Filamin A gene (FLNA) mutations are associated with …

During rodent cortex development, cells born in the medial ganglionic eminence (MGE) of
the basal telencephalon reach the embryonic cortex by tangential migration and differentiate …

Greenfield's Neuropathology, the world's leading neuropathology reference, provides a
comprehensive account of the pathological findings in neurological disease, their biological …

One way of controlling the activity of E-cadherin–a protein that is, simultaneously, a major
cell-adhesion molecule, a powerful tumour suppressor, a determinant of cell polarity and a …

Advances in neuroimaging, developmental biology and molecular genetics have increased
the understanding of developmental disorders affecting the midbrain and hindbrain, both as …

Lissencephaly–pachygyria-severe band heterotopia are diffuse neuronal migration
disorders (NMDs) causing severe, global neurological impairment. Abnormalities of the …

Cerebral cortical development involves a complex series of highly regulated steps to
generate the laminated structure of the adult neocortex. Neuronal migration is a key part of …