Malformations of cortical development (MCDs) are macroscopic or microscopic
abnormalities of the cerebral cortex that arise as a consequence of an interruption to the …

Genetic studies have identified several of the genes associated with malformations of
cortical development which might disrupt each of the main stages of cell proliferation and …

Malformations of cortical development (MCDs) are an important cause of epilepsy and an
extremely interesting group of disorders from the perspective of brain development and its …

Cell migration is a crucial event for tissue organization during development, and its
dysregulation leads to several diseases, including cancer. Cells exhibit various types of …

Neurons populating the cerebral cortex are generated during embryonic development from
neural stem and progenitor cells in a process called neurogenesis. Neural stem and …

True microcephaly (head circumference≤–3 SD), either primary (present at birth) or
secondary (of postnatal onset) results from an imbalance between progenitor cell production …

Infantile spasms constitute an age-dependent epilepsy, highly associated with cognitive
impairment, autism, and movement disorders. Previous classification systems focused on a …

The emergence of functional neuronal connectivity in the developing cerebral cortex
depends on neuronal migration. This process enables appropriate positioning of neurons …

Neurodevelopmental disorders with periventricular nodular heterotopia (PNH) are
etiologically heterogeneous, and their genetic causes remain in many cases unknown. Here …

The Arf small G proteins regulate protein and lipid trafficking in eukaryotic cells through a
regulated cycle of GTP binding and hydrolysis. In their GTP-bound form, Arf proteins recruit a …