The hyh (hydrocephalus with hop gait) mouse shows a markedly small cerebral cortex at
birth and dies postnatally from progressive enlargement of the ventricular system,. Here we …

Apical radial glia comprise the pseudostratified neuroepithelium lining the embryonic lateral
ventricles and give rise to the extensive repertoire of pyramidal neuronal subtypes of the …

Cell polarity refers to the asymmetric distribution of signaling molecules, cellular organelles,
and cytoskeleton in a cell. Neural progenitors and neurons are highly polarized cells in …

Postnatal microcephaly, intellectual disability, and progressive retinal dystrophy are major
features of autosomal recessive Cohen syndrome, which is caused by mutations in the gene …

During the past decade, substantial progress has been made in delineating clinical features
of the epilepsies and the basic mechanisms responsible for these disorders. Eleven human …

The cerebral cortex is composed of billions of morphologically and functionally distinct
neurons. These neurons are produced and organized in a regimental fashion during …

Background: Periventricular heterotopia (PH) is an etiologically heterogeneous disorder
characterized by nodules of neurons ectopically placed along the lateral ventricles. Most …

The mammalian brain consists of numerous compartments that are closely connected with
each other via neural networks, comprising the basis of higher order brain functions. The …

Epithelial cells assemble into three-dimensional aggregates to generate lumen-containing
organ substructures. Cells therein contact the extracellular matrix with their basal surface …

TDP-43 proteinopathies including frontotemporal lobar degeneration (FTLD) and
amyotrophic lateral sclerosis (ALS) are neurodegenerative disorders characterized by …