Hypertension, a well-known cardiovascular disorder noticed by rise in blood pressure,
poses a significant global health challenge. The development RNA interfering (RNAi)-based …

The with-no-lysine (WNK) kinase family, comprising four serine-threonine protein kinases
(WNK1-4), were first linked to hypertension due to their mutations in association with …

Tamm–Horsfall protein (THP) is a high-abundance urinary protein. Although its functions
have been studied for years, several aspects of these remain unclear. To achieve more …

Background Hypertension is one of the major etiologies that cause chronic kidney disease
(CKD) and can exacerbate kidney dysfunction. Zinc is an essential trace element playing a …

Uromodulin is a kidney-specific glycoprotein which is exclusively produced by the epithelial
cells lining the thick ascending limb and early distal convoluted tubule. It is currently …

Background. Hepatocyte transplantation has been extensively investigated as an alternative
to orthotopic liver transplantation. However, its application in routine clinical practice has …

Uromodulin is a nephrospecific protein that is most common in normal urine. And although it
has been known for more than 70 years, the function of uromodulin remains unclear …

Serine proteases (SPs) play physiological roles in the kidney. We previously reported that a
synthetic SP inhibitor, camostat mesilate (CM), suppressed sodium reabsorption in the renal …

І хоча він відомий більше 70 років, функція уромодуліну залишається до кінця не ясною.
Уромодулін бере участь у регулюванні транспорту солей, захищає від інфекцій …

Missense mutations in the UMOD gene encoding uromodulin cause autosomal dominant
tubulointerstitial kidney disease (ADTKD), one of the most common monogenic kidney …