Structural and non-structural proteins in SARS-CoV-2: potential aspects to COVID-19 treatment or prevention of progression of related diseases

S Kakavandi, I Zare, M VaezJalali, M Dadashi… - Cell Communication and …, 2023 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is caused by a new member of the
Coronaviridae family known as severe acute respiratory syndrome coronavirus 2 (SARS …

[HTML][HTML] Advances in the development of therapeutic strategies against COVID-19 and perspectives in the drug design for emerging SARS-CoV-2 variants

J Yin, C Li, C Ye, Z Ruan, Y Liang, Y Li, J Wu… - Computational and …, 2022 - Elsevier
Abstract Since Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was
identified in late 2019, the coronavirus disease 2019 (COVID-19) pandemic has challenged …

[HTML][HTML] Variations within the glycan shield of SARS-CoV-2 impact viral spike dynamics

ML Newby, CA Fogarty, JD Allen, J Butler… - Journal of Molecular …, 2023 - Elsevier
The emergence of SARS-CoV-2 variants alters the efficacy of existing immunity, whether
arisen naturally or through vaccination. Understanding the structure of the viral spike assists …

[HTML][HTML] Protein post-translational modification in SARS-CoV-2 and host interaction

N Cheng, M Liu, W Li, BY Sun, D Liu, G Wang… - Frontiers in …, 2023 - frontiersin.org
SARS-CoV-2 can cause lung diseases, such as pneumonia and acute respiratory distress
syndrome, and multi-system dysfunction. Post-translational modifications (PTMs) related to …

[HTML][HTML] Strategies for glycoengineering therapeutic proteins

K Dammen-Brower, P Epler, S Zhu, ZJ Bernstein… - Frontiers in …, 2022 - frontiersin.org
Almost all therapeutic proteins are glycosylated, with the carbohydrate component playing a
long-established, substantial role in the safety and pharmacokinetic properties of this …

SARS-CoV-2 Binding to Terminal Sialic Acid of Gangliosides Embedded in Lipid Membranes

G Negi, A Sharma, M Chaudhary, D Gupta… - ACS Infectious …, 2023 - ACS Publications
Multiple recent reports indicate that the S protein of SARS-CoV-2 specifically interacts with
membrane receptors and attachment factors other than ACE2. They likely have an active …

Microalgae as an efficient vehicle for the production and targeted delivery of therapeutic glycoproteins against SARS-CoV-2 variants

J Dehghani, A Movafeghi, E Mathieu-Rivet… - Marine drugs, 2022 - mdpi.com
Severe acute respiratory syndrome–Coronavirus 2 (SARS-CoV-2) can infect various human
organs, including the respiratory, circulatory, nervous, and gastrointestinal ones. The virus is …

COVID‐19 metabolism: Mechanisms and therapeutic targets

T Wang, Y Cao, H Zhang, Z Wang, CH Man… - MedComm, 2022 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) dysregulates antiviral
signaling, immune response, and cell metabolism in human body. Viral genome and …

Quantitative profiling of N-glycosylation of SARS-CoV-2 spike protein variants

Y Xie, M Butler - Glycobiology, 2023 - academic.oup.com
With the global spread of the corona virus disease-2019 pandemic, new spike variants of
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continuously emerge due …

Covid-19 infection in children and adolescents and its association with type 1 diabetes mellitus (T1d) presentation and management

K Karavanaki, K Rodolaki, A Soldatou, S Karanasios… - Endocrine, 2023 - Springer
Children seem to be affected by the new SARS-CoV-2 virus less severely than adults, with
better prognosis and low mortality. Serious complications of COVID-19 infection in children …