[HTML][HTML] COVID-19: challenges of viral variants

JL Jacobs, G Haidar, JW Mellors - Annual Review of Medicine, 2023 - annualreviews.org
The COVID-19 pandemic has been accompanied by SARS-CoV-2 evolution and
emergence of viral variants that have far exceeded initial expectations. Five major variants of …

[HTML][HTML] Serum neutralization of SARS-CoV-2 Omicron sublineages BA. 1 and BA. 2 in patients receiving monoclonal antibodies

T Bruel, J Hadjadj, P Maes, D Planas, A Seve… - Nature medicine, 2022 - nature.com
The severe acute respiratory syndrome coronavirus 2 Omicron BA. 1 sublineage has been
supplanted in many countries by the BA. 2 sublineage. BA. 2 differs from BA. 1 by about 21 …

Imprinted antibody responses against SARS-CoV-2 Omicron sublineages

YJ Park, D Pinto, AC Walls, Z Liu, A De Marco… - Science, 2022 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages carry
distinct spike mutations resulting in escape from antibodies induced by previous infection or …

COVID-19 vaccines and SARS-CoV-2 transmission in the era of new variants: A review and perspective

JR Marcelin, A Pettifor, H Janes… - Open forum …, 2022 - academic.oup.com
Abstract Coronavirus disease 2019 (COVID-19) vaccines have yielded definitive prevention
and major reductions in morbidity and mortality from severe acute respiratory syndrome …

[HTML][HTML] Neutralization of Omicron BA. 1, BA. 2, and BA. 3 SARS-CoV-2 by 3 doses of BNT162b2 vaccine

C Kurhade, J Zou, H Xia, H Cai, Q Yang… - Nature …, 2022 - nature.com
The newly emerged Omicron SARS-CoV-2 has several distinct sublineages including BA. 1,
BA. 2, and BA. 3. BA. 1 accounts for the initial surge and is being replaced by BA. 2, whereas …

[HTML][HTML] SARS-CoV-2 Omicron triggers cross-reactive neutralization and Fc effector functions in previously vaccinated, but not unvaccinated, individuals

SI Richardson, VS Madzorera, H Spencer… - Cell Host & Microbe, 2022 - cell.com
Summary The SARS-CoV-2 Omicron variant escapes neutralizing antibodies elicited by
vaccines or infection. However, whether Omicron triggers cross-reactive humoral responses …

[HTML][HTML] Molecular aspects of Omicron, vaccine development, and recombinant strain XE: A review

K Akash, A Sharma, D Kumar, SK Singh… - Journal of medical …, 2022 - ncbi.nlm.nih.gov
The global pandemic of COVID‐19 began in December 2019 and is still continuing. The
past 2 years have seen the emergence of several variants that were more vicious than each …

[HTML][HTML] Vaccine breakthrough infection leads to distinct profiles of neutralizing antibody responses by SARS-CoV-2 variant

MS Seaman, MJ Siedner, J Boucau, CL Lavine… - JCI insight, 2022 - ncbi.nlm.nih.gov
Protective immunity against SARS-CoV-2 infection after COVID-19 vaccination may differ by
variant. We enrolled vaccinated (n= 39) and unvaccinated (n= 11) individuals with acute …

[HTML][HTML] Single-epitope T cell–based vaccine protects against SARS-CoV-2 infection in a preclinical animal model

T Tada, JY Peng, BM Dcosta, NR Landau - JCI insight, 2023 - ncbi.nlm.nih.gov
Currently authorized COVID-19 vaccines induce humoral and cellular responses to epitopes
in the SARS-CoV-2 spike protein, though the relative roles of antibodies and T cells in …

Differential evasion of Delta and Omicron immunity and enhanced fusogenicity of SARS-CoV-2 Omicron BA. 4/5 and BA. 2.12. 1 subvariants

P Qu, JN Faraone, JP Evans, X Zou, YM Zheng… - BioRxiv, 2022 - biorxiv.org
The rising case numbers of the SARS-CoV-2 Omicron BA. 4, BA. 5, and BA. 2.12. 1
subvariants has generated serious concern about the course of the pandemic. Here we …