In the past decade, there has been a shift in research, clinical development, and commercial
activity to exploit the many physiological roles of RNA for use in medicine. With the rapid …

The immune microenvironment at the maternal-fetal interface was determined by the
crosstalk between the trophoblast and maternal-derived cells, which dynamically changed …

Periodontitis is a chronic osteolytic inflammatory disease resulting from complex dynamic
interactions among bacterial pathogens and the host immune response. Macrophages play …

Background RNA methylation is closely involved in immune regulation, but its role in sepsis
remains unknown. Here, we aim to investigate the role of RNA methylation-associated …

ABSTRACT RNA modifications play a vital role in multiple pathways of mRNA metabolism,
and translational regulation is essential for immune cells to promptly respond to stimuli and …

Sepsis is a life-threatening organ dysfunction caused by a host's dysfunctional response to
infection. As is known to all, septic heart disease occurs because pathogens invading the …

Abstract RNA N6-methyladenosine (m 6 A) modification is abundant in eukaryotes, bacteria
and archaea. It is an RNA modification mainly existing in messenger RNA (mRNAs) and has …

Efficient immune responses rely on the proper differentiation of CD8+ T cells into effector
and memory cells. Here, we show a critical requirement of N 6-Methyladenosine (m 6 A) …

Dental mesenchymal stem cells (DMSCs) are crucial in tooth development and periodontal
health, and their multipotential differentiation and self‐renewal ability play a critical role in …

Lymphocytes require of constant and dynamic changes in their transcriptome for timely
activation and production of effector molecules to combat external pathogens. Synthesis and …