Research waste occurs when randomised controlled trial (RCT) outcomes are
heterogeneous or overlook domains that matter to patients (eg, relating to symptoms or …

Efficacy outcomes are only informative to the extent that they are validated. We examined
the measurement properties of efficacy measures from the phase III (“RECONNECT”) …

Importance Immune-metabolic disturbances have been implicated in the pathophysiology of
major depressive disorder and may be more prominent in individuals with treatment …

Background Antipsychotic treatment may improve clinical insight. However, previous studies
have reported inconclusive findings on whether antipsychotics improve insight over and …

Background Non-serious adverse events (NSAEs) should be captured and reported
because they can have a significant negative impact on patients and treatment adherence …

Improving child and adolescent mental health requires the careful development and
rigorous testing of interventions and delivery methods. This includes universal school-based …

Randomized controlled trials can be used to generate evidence on the efficacy and safety of
new treatments in eating disorders research. Many of the trials previously conducted in this …

Introduction Developing novel antipsychotic mechanisms of action and repurposing
established compounds for the treatment of schizophrenia is of utmost importance to …

The COVID-19 pandemic has put clinical research and how it is organised, implemented,
and disseminated under scrutiny, and has revealed not only capabilities, but also …

In 2020, an estimated 91 799 people in the USA died of substance-related overdose—75%
were related to opioids, and 85% of these opioid deaths were related to fentanyl. In 2021 …