Abstract Linear Energy Transfer (LET) is widely used to express the radiation quality of ion
beams, when characterizing the biological effectiveness. However, averaged LET may be …

Simple Summary Oxygen-guided radiotherapy is a new modality for cancer irradiation.
Spatially Fractionated Radiation Therapy allows the treatment of hypoxic tumor areas with …

Purpose To evaluate the clinical potential of spot-scanning hadron arc (SHArc) therapy with
a heavy-ion gantry. Methods and Materials A series of in silico studies was conducted via …

Purpose To implement RBE calculations in treatment planning systems based on the
Microdosimetric Kinetic Model (MKM) upon analytical calculations of dose-mean lineal …

Purpose To develop and verify effective dose (D RBE) calculation in 4 He ion beam therapy
based on the modified microdosimetric kinetic model (mMKM) and evaluate the bio …

Background Hypoxia is known to be prevalent in solid tumors such as non-small cell lung
cancer (NSCLC) and reportedly correlates with poor prognostic clinical outcome. PET …

Background Variable relative biological effectiveness (RBE) models in treatment planning
have been proposed to optimize the therapeutic ratio of proton therapy. It has been reported …

In proton therapy, a constant relative biological effectiveness (RBE) factor of 1.1 is applied
although the RBE has been shown to depend on factors including the Linear Energy …

Critical advances in radionuclide therapy have led to encouraging new options for cancer
treatment through the pairing of clinically useful radiation-emitting radionuclides and …

Abstract Background and Purpose To investigate the impact of organ motion on hypoxia-
guided proton therapy treatments for non-small cell lung cancer (NSCLC) patients. Materials …