Liver fibrosis resolution: from molecular mechanisms to therapeutic opportunities

Q Pei, Q Yi, L Tang - International Journal of Molecular Sciences, 2023 - mdpi.com
The liver is a critical system for metabolism in human beings, which plays an essential role
in an abundance of physiological processes and is vulnerable to endogenous or exogenous …

[HTML][HTML] Protein tyrosine phosphatase 1B (PTP1B) as a potential therapeutic target for neurological disorders

J Olloquequi, A Cano, E Sanchez-López… - Biomedicine & …, 2022 - Elsevier
Protein tyrosine phosphatase 1B (PTP1B) is a typical member of the PTP family, considered
a direct negative regulator of several receptor and receptor-associated tyrosine kinases …

Ferulic acid exhibits anti-inflammatory effects by inducing autophagy and blocking NLRP3 inflammasome activation

Y Liu, L Shi, W Qiu, Y Shi - Molecular & cellular toxicology, 2022 - Springer
Background Inflammation is involved in the healing process; however, when inflammation is
overactivated, multiple diseases can occur. The continued discovery of new anti …

[HTML][HTML] PTP1B inhibitors protect against acute lung injury and regulate CXCR4 signaling in neutrophils

D Song, JM Adrover, C Felice, LN Christensen, XY He… - JCI insight, 2022 - ncbi.nlm.nih.gov
Acute lung injury (ALI) can cause acute respiratory distress syndrome (ARDS), a lethal
condition with limited treatment options and currently a common global cause of death due …

Effects of ferulic acid, a major component of rice bran, on proliferation, apoptosis, and autophagy of HepG2 cells

J Wang, X Lai, D Yuan, Y Liu, J Wang… - Food Research …, 2022 - Elsevier
Ferulic acid is an active substance that can inhibit the growth of cancer cells, and it also
shows antioxidant activity. Previous studies examined the effect of ferulic acid as a …

Anti-angiogenic effects of natural compounds in diet-associated hepatic inflammation

S Novi, V Vestuto, P Campiglia, N Tecce, A Bertamino… - Nutrients, 2023 - mdpi.com
Alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) are the most
common causes of chronic liver disease and are increasingly emerging as a global health …

Aurantio-obtusin attenuates non-alcoholic fatty liver disease through AMPK-mediated autophagy and fatty acid oxidation pathways

F Zhou, M Ding, Y Gu, G Fan, C Liu, Y Li… - Frontiers in …, 2022 - frontiersin.org
Nonalcoholic fatty liver disease (NAFLD), manifested as the aberrant accumulation of lipids
in hepatocytes and inflammation, has become an important cause of advanced liver …

Traditional Chinese medicine in regulating macrophage polarization in immune response of inflammatory diseases

S Chen, J Zeng, R Li, Y Zhang, Y Tao, Y Hou… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Numerous studies have demonstrated that various
traditional Chinese medicines (TCMs) exhibit potent anti-inflammatory effects against …

Advances in the therapeutic application and pharmacological properties of kinsenoside against inflammation and oxidative stress-induced disorders

L Lu, Y Xiong, Z Lin, X Chu, AC Panayi, Y Hu… - Frontiers in …, 2022 - frontiersin.org
Extensive research has implicated inflammation and oxidative stress in the development of
multiple diseases, such as diabetes, hepatitis, and arthritis. Kinsenoside (KD), a bioactive …

Natural products in pursuing novel therapies of nonalcoholic fatty liver disease and steatohepatitis

H Li, T Guan, S Qin, Q Xu, L Yin, Q Hu - Drug Discovery Today, 2023 - Elsevier
Highlights•Many natural products ameliorate nonalcoholic fatty liver disease and
nonalcoholic steatohepatitis via various mechanisms.•Alkaloids and terpenoids deserve …