The interplay between chromatin, transcription factors and genes generates complex
regulatory circuits that can be represented as gene regulatory networks (GRNs). The study …

The assay for transposase-accessible chromatin using sequencing (ATAC-seq) provides a
simple and scalable way to detect the unique chromatin landscape associated with a cell …

cis-Regulatory elements encode the genomic blueprints that ensure the proper
spatiotemporal patterning of gene expression necessary for appropriate development and …

With biotechnological advancements, innovative omics technologies are constantly
emerging that have enabled researchers to access multi-layer information from the genome …

Distribution shifts—where the training distribution differs from the test distribution—can
substantially degrade the accuracy of machine learning (ML) systems deployed in the wild …

Summary cis-regulatory elements (CREs) encode the genomic blueprints of spatiotemporal
gene expression programs enabling highly specialized cell functions. Using single-cell …

Single-cell assay for transposase-accessible chromatin by sequencing (scATAC-seq) has
emerged as a powerful tool for dissecting regulatory landscapes and cellular heterogeneity …

The maturation of high-throughput short-read sequencing technology over the past two
decades has shaped the way genomes are studied. Recently, single-molecule, long-read …

Chromatin accessibility is integral to the process by which transcription factors (TFs) read out
cis-regulatory DNA sequences, but it is difficult to differentiate between TFs that drive …

Sensory neurons in the dorsal root ganglion (DRG) and trigeminal ganglion (TG) are
specialized to detect and transduce diverse environmental stimuli to the central nervous …